系统性免疫炎症指数和无回流之间的关系,在穿皮冠状动脉干预中,用于saphenous graft
Gökhan Demirci1, Ahmet A Şahin2, Tuğba Aktemur1
1University of Health Sciences, Department of Cardiology, Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital, Istanbul, Turkey.
Biomarkers in medicine
|July 14, 2023
概括
高系统性免疫炎症指数 (SII) 表示炎症增加和无回流 (NR) 的更高风险在静脉移植 (SVG) 穿皮冠状动脉干预 (PCI) 期间. 这一发现对于管理患有SVG疾病的患者至关重要.
科学领域:
- 心脏病学 心脏病学
- 干预心脏病学 干预心脏病学
- 炎症生物标志物 炎症生物标志物
背景情况:
- 沙芬静脉移植 (SVG) 疾病是冠状动脉旁路移植后的常见并发症.
- 皮肤冠状动脉干预 (PCI) 经常用于治疗SVG疾病,但它与无反流 (NR) 的显著风险有关.
- 系统性免疫炎症指数 (SII) 是一种新的系统性炎症标志物.
研究的目的:
- 为了调查在SVG疾病的PCI期间出现无反流 (NR) 的情况.
- 在接受SVG PCI的患者中检查SII和NR之间的关系.
- 评估SII作为该患者群体中NR的潜在预测因素.
主要方法:
- 研究了一组303名患有急性冠状动脉综合征而没有ST升高的患者,他们接受了针对SVG疾病的PCI.
- 根据患者的SII水平,患者被划分为几组.
- 在PCI期间NR的发病率在低SII和高SII的组之间进行了比较.
主要成果:
- 在高SII患者 (p < 0.001) 中,NR发生的频率显著增加.
- 在SII ≤548患者中,NR发生率为12.8%,而SII>548.9患者中为41.9%.
- 较高的SII水平与SVG PCI期间NR的风险增加密切相关.
结论:
- 这项研究是第一个在SVG PCI中探索SII和NR之间的关联.
- 升高的SII是SVG疾病PCI期间NR的显著预测因素.
- SII可以作为一种有价值的炎症标志物,用于识别 NR 风险较高的患者,指导临床管理.
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