一个基于时间的双面阅读概念,用于未来的轴向TOF-PET的100毫米LYSO:Ce,Ca纤维
Konstantin Weindel1, Vanessa Nadig1, Katrin Herweg1
1Department of Physics of Molecular Imaging Systems, Institute for Experimental Molecular Imaging, RWTH Aachen University, Aachen, Germany.
EJNMMI physics
|July 14, 2023
概括
pozitron发射断层扫描 (PET) 扫描仪中的更长的闪晶体提供了更好的飞行时间 (TOF) 解析度和灵敏度. 这项研究表明,LYSO:Ce,Ca纤维的双面读取实现了出色的定时和交互深度分辨率,可能降低成本.
科学领域:
- 核仪器仪表 核仪器仪表 核仪器仪表
- 医学成像物理 医学成像物理
背景情况:
- pozitron发射断层扫描 (PET) 需要高的信号噪声比 (SNR) 图像质量,飞行时间 (TOF) 提高SNR.
- 较长的闪晶体 (例如100毫米LYSO:Ce,Ca) 具有双面读出,可以通过深度交互 (DOI) 估计来改善TOF,灵敏度和减少抛物误差.
- 轴对齐的长纤维可能有助于在混合系统中与MRI进行集成,并减少读出通道的要求,以实现成本效益.
研究的目的:
- 调查PET成像新兴高性能材料的定时性能和DOI分辨率.
- 评估在器官专用或全身PET系统中使用长轴对齐的闪光晶体与双面读取的优点.
- 评估实现突破性的TOF和灵敏度的可行性,同时保持扫描器分辨率.
主要方法:
- 测试了各种配置的LYSO:Ce,Ca闪光纤 (20毫米和100毫米长).
- 通过使用最先进的高频 (HF) 读数来确定巧合时间分辨率 (CTR) 和DOI分辨率.
- 我使用了来自Broadcom Inc.的商用光倍增器 (SiPM) 来进行读取.
主要成果:
- 100毫米纤维的平均CTR达到[公式:参见文本]ps FWHM,DOI分辨率达到[公式:参见文本]mm FWHM.
- 20毫米纤维在双面读取中显示出[公式:参见文本]ps FWHM的CTR小于100ps和[公式:参见文本]mm FWHM的纤维分辨率.
- 空间分辨率在轴向上被限制在12mm,但在其他方向上被定义为3mm.
结论:
- 长LYSO:Ce,Ca纤维的双面读数与现代SiPM实现了出色的定时和TOF分辨率,超过了商业PET系统.
- 显著减少电子通道 (大约. 100毫米纤维的2.5倍) 是可以实现的,从而降低了潜在的成本.
- 未来的原型预计将进一步改进基于最近的SiPM和闪电器发展的时间和空间分辨率.
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