液体活检在风湿性关节炎中的作用
Lin Bo1, Xiaojia Jin1, Yaqi Hu1
1Department of Rheumatology, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Methods in molecular biology (Clifton, N.J.)
|July 14, 2023
概括
早期风湿性关节炎 (RA) 诊断至关重要. 液体活检提供了有前途的生物标志物,可以比传统测试更快地检测RA,从而改善治疗结果.
科学领域:
- 免疫学 免疫学 免疫学
- 生物标志物 生物标志物
- 分子诊断学 分子诊断
背景情况:
- 类风湿性关节炎 (RA) 是一种由遗传和环境因素影响的慢性自身免疫性疾病.
- 早期诊断RA对于有效的治疗和预后至关重要.
- 目前的诊断方法,包括类风湿因子和抗循环素抗体测试,在早期检测方面存在局限性.
结论:
- 液体活检技术为早期检测类风湿性关节炎提供了一种新的策略.
- 这种方法可能会导致RA患者更精确,更有效的治疗干预措施.
- 对液体活检生物标志物的进一步研究可能会彻底改变RA管理.
相关概念视频
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
38
The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
38
Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF
175
Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
175


