在冠状动脉心脏病中的液体活检
Wenyan Zhu1,2, Xiang Li3
1Chongqing Engineering Research Center of Pharmaceutical Sciences, Chongqing Medical and Pharmaceutical College, Chongqing, China.
Methods in molecular biology (Clifton, N.J.)
|July 14, 2023
概括
液体活检提供了一种非侵入性的方法来检测冠心病 (CHD) 的生物标志物. 这种液体活检技术分析循环中的分子,用于早期诊断,治疗监测和改善心血管疾病的预后.
科学领域:
- 心血管医学 心血管医学
- 分子诊断学 分子诊断
- 精准医学是一门精准的医学.
背景情况:
- 心血管疾病 (CVD),特别是冠心病 (CHD),是全球主要的死亡原因.
- 目前对心血管疾病的诊断和治疗策略越来越多地采用精准医学方法.
- 敏感的生物标志物对于早期心脏病诊断和改善患者治疗结果至关重要.
研究的目的:
- 审查液体活检的最新进展,以准确诊断和治疗心脏病.
- 探索液体活检在治疗慢性病的当前应用和未来临床前景.
- 突出液体活检在推进精准医学和心血管疾病个性化治疗方面的重要性.
主要方法:
- 液体活检分析在体液 (血液,唾液,尿液) 中的循环细胞或它们的产物,以检测分子变化.
- 检测无细胞DNA (cfDNA) 水平,以预测急性心肌梗塞的严重程度和移植排斥.
- 对血循环中的microRNA-92 (miR-92) 水平进行监测,以预测糖尿病患者的急性冠状动脉综合征 (ACS).
- 研究非甲基化FAM101A基因作为缺血期间心肌细胞亡的生物标志物.
主要成果:
- 液体活检为检测心血管疾病生物标志物提供了组织活检的微创替代方案.
- 像cfDNA和miR-92这样的特定生物标志物显示出预测心血管疾病严重程度,并发症和风险的潜力.
- 循环分子的分析为持续的CHD监测提供了动态和全面的分子信息.
结论:
- 液体活检具有早期预警,辅助诊断和心脏病风险分层的巨大潜力.
- 它可以实时监测治疗疗效,指导药物治疗,并有助于了解耐药性机制.
- 液体活检的进步支持准确医学和个性化治疗策略在心血管护理中的日益重要.
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