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相关概念视频

Protein Networks02:26

Protein Networks

4.0K
An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
4.0K
Protein-protein Interfaces02:04

Protein-protein Interfaces

12.6K
Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a...
12.6K
Protein-Protein Interfaces02:04

Protein-Protein Interfaces

3.8K
3.8K
Protein Complexes with Interchangeable Parts01:57

Protein Complexes with Interchangeable Parts

2.6K
Groups of proteins may form a complex where each protein in this complex has a different role in the overall execution of the complex’s function. Often some of the proteins in the complex can be replaced by a closely related variant to give a complex that contains many of the same components yet is functionally distinct.
The SCF ubiquitin ligase is a protein complex of five individual proteins. This complex attaches ubiquitin to other target proteins to mark them for degradation. In order...
2.6K

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相关实验视频

Updated: Jul 23, 2025

Label-Free Immunoprecipitation Mass Spectrometry Workflow for Large-scale Nuclear Interactome Profiling
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Label-Free Immunoprecipitation Mass Spectrometry Workflow for Large-scale Nuclear Interactome Profiling

Published on: November 17, 2019

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蛋白与蛋白相互作用网络探索使用细胞图.

Aqsa Majeed1, Shahid Mukhtar2

  • 1Department of Biology, University of Alabama at Birmingham, Birmingham, AL, USA.

Methods in molecular biology (Clifton, N.J.)
|July 14, 2023
PubMed
概括
此摘要是机器生成的。

这项研究展示了使用Cytoscape可视化和分析蛋白质-蛋白质相互作用 (PPI) 网络. 它突出了细胞景观.

关键词:
集中性的分析分析.城市景观 (cytoscape) 是一个关于城市的景观.网络生物学 网络生物学网络可视化 网络可视化在PPI网络模块中.蛋白质蛋白质相互作用

更多相关视频

Genome-wide Protein-protein Interaction Screening by Protein-fragment Complementation Assay PCA in Living Cells
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Genome-wide Protein-protein Interaction Screening by Protein-fragment Complementation Assay PCA in Living Cells

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Quantification of Protein Interaction Network Dynamics using Multiplexed Co-Immunoprecipitation
00:07

Quantification of Protein Interaction Network Dynamics using Multiplexed Co-Immunoprecipitation

Published on: August 21, 2019

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相关实验视频

Last Updated: Jul 23, 2025

Label-Free Immunoprecipitation Mass Spectrometry Workflow for Large-scale Nuclear Interactome Profiling
11:19

Label-Free Immunoprecipitation Mass Spectrometry Workflow for Large-scale Nuclear Interactome Profiling

Published on: November 17, 2019

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Genome-wide Protein-protein Interaction Screening by Protein-fragment Complementation Assay PCA in Living Cells
08:38

Genome-wide Protein-protein Interaction Screening by Protein-fragment Complementation Assay PCA in Living Cells

Published on: March 3, 2015

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Quantification of Protein Interaction Network Dynamics using Multiplexed Co-Immunoprecipitation
00:07

Quantification of Protein Interaction Network Dynamics using Multiplexed Co-Immunoprecipitation

Published on: August 21, 2019

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科学领域:

  • 系统生物学 系统生物学
  • 生物信息学是一种生物信息学.
  • 计算生物学 计算生物学

背景情况:

  • 蛋白质与蛋白质相互作用 (PPI) 数据正在迅速扩大.
  • 分析PPI网络有助于识别功能模块和基因功能.

研究的目的:

  • 为了说明Cytoscape用于PPI网络可视化和分析的应用.
  • 展示Cytoscape处理复杂生物网络的功能.

主要方法:

  • 使用Cytoscape,这是一个用于网络分析的开源软件.
  • 应用Cytoscape可视化和分析阿拉比多普西斯互动蛋白-1主 (AI-1 MAIN) PPI数据集.

主要成果:

  • 证明了AI-1 MAIN PPI网络的有效可视化.
  • 展示了Cytoscape在导航,过和分析网络数据方面的功能.

结论:

  • 赛托斯凯普是系统生物学研究的强大工具,涉及PPI网络.
  • 这项研究提供了Cytoscape对生物网络分析的实用性的实用例子.