在性别确认激素治疗之前,跨性别成年人的骨健康和身体组成:来自COMET研究的数据
C Ceolin1,2, A Scala3,4, M Dall'Agnol5
1Geriatrics Division, Department of Medicine (DIMED), University of Padua, Padua, Italy. chiara.ceolin.1@gmail.com.
Journal of endocrinological investigation
|July 14, 2023
概括
开始性别确认激素治疗的跨性别成年人可能具有较低的骨矿物质密度 (BMD). 身体成分和生活方式因素,如吸烟和体育活动,似乎会影响该人口的BMD.
科学领域:
- 内分泌学 在内分泌学.
- 骨的新陈代谢 骨的新陈代谢
- 跨性别者健康 跨性别者健康
背景情况:
- 初步数据表明,在性别确认激素治疗 (GAHT) 之前,与异性对照组相比,跨性别成年人骨矿物质密度 (BMD) 较低.
- 在GAHT发生之前了解跨性别个体的骨代谢对于早期干预至关重要.
研究的目的:
- 在GAHT之前分析跨性别成年人的骨代谢.
- 为了研究骨代谢,生化资料,身体组成和生活习惯之间的相关性.
主要方法:
- 一项涉及125名跨性别成年人和146名西斯性别对照者的研究在GAHT之前.
- 收集医疗数据,吸烟习惯,血液测试 (酸盐,荷尔蒙) 和密度计参数.
- 用国际体育活动问卷 (IPAQ) 评估参与者的身体组成和体育活动.
主要成果:
- 低BMD (z-score < -2) 的更高患病率在跨性别个体 (14.3%) 与 cisgender 对照组 (6.2%) 相比观察到.
- 变性人群的维生素D水平较低.
- 他们注意到身体组成的差异:AFAB变性人群的脂肪质量较高,而AMAB变性人群的瘦质量较低. 主动吸烟和室内习惯在AFAB跨性别成年人中更为普遍.
结论:
- 身体组成和生活方式因素,包括吸烟和体育活动,可能会在开始GAHT之前导致跨性别成年人骨矿物质密度下降.
- 需要进一步的研究来阐明这些因素的复杂相互作用.
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