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不同的慢性压力模式汇聚在内源性TDP43裂变和聚合上

Niccolò Candelise1,2, Daniela Caissutti1, Henri Zenuni3

  • 1Department of Experimental Medicine, University La Sapienza, 00185, Rome, Italy.

Molecular neurobiology
|July 14, 2023
PubMed
概括

细胞中的慢性压力通过诱导TAR-DNA结合蛋白 (TDP43) 聚合并形成致病碎片,更好地模拟肌缩侧面硬化症 (ALS). 这项研究还优化了一种检测活细胞中TDP43子的方法.

关键词:
骨髓缩侧面硬化症 (ALS) 是一种慢性压力是一种慢性压力.普里昂 (Prion) 是一个子.在TDP43中使用.提奥夫拉文是第一个.

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