遗传学在早产中的作用
Elyse C Mead1, Carol A Wang1,2, Jason Phung1,2,3
1School of Medicine and Public Health, University of Newcastle, Newcastle, NSW, 2308, Australia.
Reproductive sciences (Thousand Oaks, Calif.)
|July 14, 2023
概括
对早产 (PTB) 的遗传研究揭示了复杂的风险因素. 整合多个" -omics"数据显示了预测PTB的前景,与单个数据方法不同.
科学领域:
- 遗传学 遗传学 是一个
- 生殖健康 生殖健康
- 周围生理学 周围生理学
背景情况:
- 早产 (PTB) 影响11%的活产,是婴儿死亡的主要原因.
- 遗传变异是PTB的重要风险因素.
- 以前的研究已经探索了与PTB相关的各种生物学途径.
研究的目的:
- 提供关于早产遗传学的当前研究的全面审查.
- 总结有关遗传标记及其与PTB风险相关性的发现.
- 评估不同基因和多种基因学方法在理解PTB方面的有效性.
主要方法:
- 在PubMed进行了一项文献搜索,以寻找有关PTB遗传学的英语研究.
- 包括专注于遗传关联,途径分析和多omics数据集成的研究.
- 评估了已识别的遗传变异的力量和可复制性.
主要成果:
- 炎症,免疫,内分泌,代谢和血管路径中的基因与PTB有关.
- 许多发表的遗传研究缺乏足够的力量,并产生了不确定的结果.
- 大规模的,没有假设的研究发现并复制了与PTB相关的新型变异.
- 单个基因组数据集 (基因组,转录组,表观组) 在PTB预测方面基本上没有成功.
- 多omics数据的整合显示了PTB预测最有前途的结果.
结论:
- 过早分娩的遗传学是复杂的,涉及多个生物途径.
- 单个米方法对于临床PTB预测是不够的.
- 整合来自多个omics数据集的数据为推进PTB研究和临床应用提供了最有前途的途径.
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