在急性炎症中,线粒体反应性氧物种和性编程细胞死亡
Sergio Rius-Pérez1,2, Salvador Pérez1, Michel B Toledano3
1Department of Physiology, Faculty of Pharmacy, University of Valencia, Spain.
Antioxidants & redox signaling
|July 14, 2023
概括
线粒体反应性氧物种 (mtROS) 是调控细胞死亡 (RCD) 和炎症的关键调节者. 了解mtROS在死,铁和热中的作用为急性炎症疾病提供了新的治疗点.
科学领域:
- 生物化学 生物化学
- 细胞生物学 细胞生物学
- 免疫学 免疫学 免疫学
背景情况:
- 线粒体反应性氧物种 (mtROS) 涉及到各种调节细胞死亡 (RCD) 途径,包括亡,亡,铁亡和热亡.
- 虽然mtROS在亡中的作用得到了充分的研究,但它们在死类RCD和炎症性疾病中的参与是新兴的研究领域.
研究的目的:
- 阐明mtROS在不同RCD机制 (死,铁,热) 中的特定作用及其对急性炎症的贡献.
- 探索线粒体抗氧化剂作为治疗炎症状况的治疗策略的潜力.
主要方法:
- 这项研究回顾了现有的文献和关于RCD通路中的氧化还原信号和mtROS的研究.
- 它分析了将mtROS与特定的RCD类型联系在一起的分子机制,包括关键蛋白质和涉及的途径.
主要成果:
- 3.mtROS与p53结合,通过降低硫胺和氧胺的调节来驱动亡.
- 线粒体基酸脱酶被确定为铁灭中的关键氧化还原调节剂.
- 一个涉及Ragulator-Rag-mTORC1复合体的非正规途径产生mtROS,通过气体皮质D寡合化促进热致死.
结论:
- 通过各种RCD途径,mtROS积极促进炎症性疾病,通常涉及积极的反循环.
- 需要进一步的研究来澄清mtROS在铁灭膜破裂中的作用及其对炎症性疾病的具体贡献.
- 线粒体抗氧化剂对急性炎症具有治疗性前景,但谨慎的剂量和时间是平衡疗效和避免抑制有益的mtROS信号的关键.
关键词:
铁性化 (ferroptosis) 是一种过氧化是一种过氧化.线粒体中的线粒体.尸体亡 (necroptosis) 是一种致死症.热致灭 (pyroptosis) 是一种致的过程.这是一种超氧化离子.更多相关视频
06:12Author Spotlight: THP-1 Macrophage Response to LPS/ATP — Unveiling the Pyroptosis, Apoptosis, and Necroptosis Spectrum
Published on: May 3, 2024
2.0K
09:18Identification of Intracellular Signaling Events Induced in Viable Cells by Interaction with Neighboring Cells Undergoing Apoptotic Cell Death
Published on: December 27, 2016
8.7K
相关概念视频
01:38Inflammation
53.9K
Overview
53.9K
01:30Inflammatory Response I: Vascular and Cellular
11.4K
The inflammatory response is the body's defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps locate and destroy pathogens and remove damaged tissue elements to heal the body. During this initial phase, fluid, blood products, and nutrients migrate to the injured area, resulting in redness, heat, swelling, ache, and loss of function. Moreover, signs of systemic inflammation include fever, increased WBC count, malaise, anorexia, nausea,...
11.4K
01:30Apoptosis
11.6K
Apoptosis is a combination of two Greek words, 'apo' and 'ptosis,' meaning separation and falling off, respectively. Hippocrates used this word to describe gangrene, which was caused due to bandaging of fractured bones. Apoptosis was distinguished from necrosis in 1970 when John Kerr reported observations of morphological changes occurring during apoptosis. During one experiment, he observed that the disruption of blood supply to the liver tissue resulted in a size...
11.6K
01:28Inflammatory Response
2.2K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
2.2K
01:16Necrosis
4.6K
Necrosis is considered as an “accidental” or unexpected form of cell death that ends in cell lysis. The first noticeable mention of “necrosis” was in 1859 when Rudolf Virchow used this term to describe advanced tissue breakdown in his compilation titled “Cell Pathology”.
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become...
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become...
4.6K
01:31The Intrinsic Apoptotic Pathway
6.6K
Internal cellular stress, such as cellular injury or hypoxia, triggers intrinsic apoptosis. The B-cell lymphoma 2 (Bcl-2) family of proteins are the primary regulators of the intrinsic apoptotic pathway. For example, during DNA damage, checkpoint proteins, such as Ataxia Telangiectasia Mutated (ATM protein) and Checkpoints Factor-2 (Chk2) proteins, are activated. These proteins phosphorylate p53 which further activates pro-apoptotic proteins, such as Bax, Bak, PUMA, and Noxa, and inhibits...
6.6K