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胃肠道粘膜母细胞的量化:实践病理学家的入门书

Robert M Genta^1,2, Kevin O Turner^2,3, Margaret H Collins⁴

¹From the Departments of Pathology and Medicine (Gastroenterology), Baylor College of Medicine, Houston, Texas (Genta).

Archives of pathology & laboratory medicine

|July 14, 2023

概括

病理学家现在有一种标准化的方法来计算消化组织中质细胞的数量. 这种方法有助于诊断胃肠道疾病,并指导临床管理.

科学领域:

胃肠病学胃肠病学
免疫学免疫学免疫学
病理学病理学病理学

背景情况:

乳腺细胞是关键的免疫细胞,参与消化系统疾病,如乳腺细胞肠炎和eosinophilic胃肠道疾病.
由于越来越多的人意识到它们在功能性胃肠道疾病中的作用,病理学家对胃肠道活检中巨细胞分布和密度的评估变得越来越重要.

研究的目的:

为病理学家提供一种系统的方法,用于评估,计数和报告食道,胃和肠道样本中的乳腺细胞.
建立标准化工具,用于对胃肠道病理的巨细胞评估.

主要方法:

一个全面的文献综述135篇关于消化道中乳腺细胞的论文.
选择了21项研究,详细介绍了巨细胞计数方法.
达成共识的会议涉及文献审查和专家经验,以定义可计数的巨细胞和计数策略.

主要成果:

建立了关于不同肠道段的正常乳腺细胞数量的共识.
根据形态学定义了识别可计数乳腺细胞的标准.
在胃肠道活检中推的瘤细胞计数的特定位置和策略.

结论:

开发了一种系统的方法,用于在GI标本中评估乳腺细胞.
提供了报告巨细胞计数,分布和位置的指导方针.
促进病理学家和临床医生之间更清晰的沟通,以改善患者管理.

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