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生殖因素和外源性雌激素与全球和特定领域的认知在晚年生活中的关联
Jillian K Lee1, Ryan D Frank2, Luke R Christenson2
1Department of Epidemiology and Prevention, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
概括
生殖因素,如平价和荷尔蒙避孕 (HC) 影响老年妇女的认知能力下降. 虽然更高的平价率和更年期晚期的荷尔蒙疗法 (MHT) 使用与衰退有关,但HC使用显示出保护作用.
科学领域:
- 神经科学是一个神经科学.
- 生殖健康 生殖健康
- 老年学是一门学科.
背景情况:
- 生殖因素对认知衰老的影响仍然不完全理解.
- 很少有研究全面评估生殖史对晚年认知功能的影响.
研究的目的:
- 研究女性生殖因素与认知轨迹之间的关联.
- 检查生殖窗口长度,平价,激素避孕 (HC) 和更年期激素治疗 (MHT) 对认知领域的影响.
主要方法:
- 一项基于人口的研究,对2458名女性 (平均年龄74.2岁) 进行临床评估和认知测试.
- 在多个领域对认知表现的纵向分析.
主要成果:
- 较高的平价与所有领域的加速认知衰退相关.
- 曾经使用荷尔蒙避孕药 (HC) 与保存的全球和域特定认知有关.
- 曾经使用更年期激素治疗 (MHT),特别是开始>5年更年期后,与加速的认知衰退有关.
结论:
- 繁殖因素,包括平价和MHT使用时间,是认知衰老的重要决定因素.
- 荷尔蒙避孕可以在晚年提供认知保护.
- 开始MHT的时间对其认知影响至关重要.
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