相关实验视频

Updated: Jul 23, 2025

A Tripeptide-Stabilized Nanoemulsion of Oleic Acid

A Tripeptide-Stabilized Nanoemulsion of Oleic Acid

Published on: February 27, 2019

提供口服和蛋白质的挑战和机遇

Haisheng Peng^1,2, Jiahe Wang³, Jiayu Chen¹

¹Department of Pharmacology, Medical College, University of Shaoxing, Shaoxing, China.

Expert opinion on drug delivery

|July 14, 2023

概括

开发口服蛋白质治疗药物面临着胃肠道挑战,如降解和吸收不良. 需要创新策略来克服这些障碍,以改善患者的合规性和降低成本.

科学领域:

生物工程是生物工程.
药物运输药物运输药物运输
生物技术是生物技术.

背景情况:

复杂的蛋白质在治疗疾病方面比小分子药物具有优势.
口服蛋白质剂量形式有望改善患者的遵守性和降低制造成本.
胃肠道环境对口服蛋白质的输送构成重大挑战,包括酶降解和吸收不良.

研究的目的:

审查口服输送和复杂蛋白质的障碍.
描述当前的口服交付策略.
确定促进口服蛋白质输送的机遇和挑战.

主要方法:

目前研究和临床试验的文献综述.
对现有的口服蛋白质药物和输送策略的分析.
检查 *体外* 和 *体内* 的动物数据.

主要成果:

口服蛋白质输送的重大障碍包括酶降解,低透性和弱吸收.
目前正在探索克服这些挑战的战略.
有限的临床数据和对动物模型的依赖对人类的安全性和有效性存在不确定性.

结论:

设计有效的蛋白质口服输送策略仍然是一个重大挑战.
需要新的想法,创新的设计和新型模型系统.
推进口服蛋白质输送需要进一步的研究和临床验证.

关键词:

口服蛋白质是一种口服蛋白质.吸收障碍物吸收障碍物提供先进的药物输送.临床试验是指临床试验中的临床试验.蛋白质药物市场蛋白质药物市场

更多相关视频

Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation

Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation

Published on: January 26, 2016

Solubility of Hydrophobic Compounds in Aqueous Solution Using Combinations of Self-assembling Peptide and Amino Acid

Solubility of Hydrophobic Compounds in Aqueous Solution Using Combinations of Self-assembling Peptide and Amino Acid

Published on: September 20, 2017

相关概念视频

Drug Delivery: Overview

Drug Delivery: Overview

The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...

Drug Delivery: Enteral Route

Drug Delivery: Enteral Route

The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.

Protein Digestion

Protein Digestion

Protein digestion begins in the stomach, where the highly acidic environment can easily disrupt protein structure by exposing the peptide bonds of polypeptide chains. After polypeptide chains are broken into individual amino acids by a series of digestive enzymes, the amino acids are transported to the liver via the bloodstream to produce energy.