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Updated: Jul 23, 2025

In Vitro Analysis of E3 Ubiquitin Ligase Function
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Published on: May 14, 2021

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通过KCTD5/Cullin3 E3结合酶对G蛋白βγ子单元的无处不在的结构基础

Wentong Jiang1,2, Wei Wang2,3, Yinfei Kong4

  • 1Graduate School of Peking Union Medical College, Beijing 100730, China.

Science advances
|July 14, 2023
PubMed
概括

一种新型的 pentameric E3 酶,KCTD5,通过无处不在的 Gβγ 子单元调节 G 蛋白结合受体 (GPCR) 信号传递. 这种机制微调循环腺单酸盐 (cAMP) 信号,揭示了 KCTD 蛋白质作为关键的 GPCR 调节器.

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