从非编码RNA的角度来解码肝癌发生
Mostafa K Abd El-Aziz1,2, Alyaa Dawoud3, Caroline J Kiriacos3
1Biochemistry Department, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut, Egypt.
Journal of cellular physiology
|July 14, 2023
概括
长非编码RNAs (lncRNAs) 和圆形RNAs (circRNAs) 越来越多地与肝细胞癌 (HCC) 的发展有关. 了解它们的作用为HCC诊断,预后和药物开发提供了新的途径.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 遗传学 遗传学 是一个
背景情况:
- 肝细胞癌 (HCC) 是一种主要的全球性癌症,肝脏瘤发生机制尚不清楚.
- 虽然研究了microRNAs,但长非编码RNAs (lncRNAs) 和圆形RNAs (circRNAs) 在HCC中的作用仍未得到研究.
- lncRNAs调节各种细胞功能,它们的失调与HCC的各种病因有关.
研究的目的:
- 审查最近在HCC病理生理学中关于lncRNA和circRNA失调的发现.
- 探索lncRNAs和circRNAs作为HCC新型诊断和预后生物标志物的潜力.
- 讨论未来的趋势和针对HCC中的lncRNAs和circRNAs的治疗策略.
主要方法:
- 关于最近有关HCC的lncRNA和circRNA研究突破的文献综述.
- 对lncRNAs和circRNAs在HCC进展中的病理作用的分析.
- 基于lncRNA和circRNA目标的潜在药物开发策略的讨论.
主要成果:
- lncRNAs和circRNAs在HCC病理生理学中起着重要作用.
- 失调的lncRNAs和circRNAs显示出作为诊断和预后生物标志物的前景.
- 这些非编码RNAs影响HCC的增殖,迁移和上皮细胞到介质细胞的过渡.
结论:
- lncRNAs和circRNAs代表了理解HCC的关键研究领域.
- 准lncRNAs和circRNAs有可能用于新的HCC诊断,预后和治疗应用.
- 对lncRNAs和circRNAs的进一步研究可以推动有效的HCC药物开发.
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