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一种名图,用于预测阴性MRI的男性中临床显著前列腺癌的缺失

Masatomo Kaneko^1,2, Atsuko Fujihara^1,2, Tsuyoshi Iwata^1,2

¹USC Institute of Urology and Catherine & Joseph Aresty, Center for Image-Guided Surgery, Focal Therapy, and Artificial Intelligence for Prostate Cancer, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.

International braz j urol : official journal of the Brazilian Society of Urology

|July 14, 2023

概括

这项研究开发了一种名谱来预测阴性MRI扫描的男性临床显著前列腺癌 (CSPCa) 缺席,从而可能避免不必要的活检. 黑人男性的CSPCa风险更高,即使有负面成像.

科学领域:

泌尿器科泌尿器科泌尿器科泌尿器科
放射学放射学是一门学科.
在瘤学瘤学.

背景情况:

多参数磁共振成像 (mpMRI) 对于前列腺癌 (PCa) 检测至关重要.
负的mpMRI (前列腺成像报告和数据系统得分1-2) 可以减少不必要的前列腺活检 (PBx).
需要预测工具来完善对非可疑的mpMRI结果的男性的决策.

研究的目的:

开发一个预测临床上显著前列腺癌 (CSPCa) 缺失的诺姆图,用于接受PBx.mpMRI检测的阴性男性.
确定影响该患者群体中CSPCa风险的因素.
关于PBx.的必要性,帮助做出决定.

主要方法:

对327名患者进行3TmpMRI和随后的PBx的回顾性分析.
包括患有前列腺成像报告和数据系统得分1-2的患者.
多变量逻辑回归确定了CSPCa (等级组≥2) 的预测因子;使用AUROC和启动测试来评估nomogram性能.

主要成果:

在13%的患者中诊断出CSPCa.
CSPCa的独立预测因素包括黑人种族,以前的负PBx和PSA密度 (PSAD) ≥0.15 ng/mL2.2.
这个名ogram 获得了 0.78 的 AUROC (乐观度调整后的 0.75).

结论:

开发的诺米图有助于评估个体CSPCa的概率,男性有PIRADS 1-2 mpMRI,潜在地确定可以避免PBx的候选人.
黑人男性面临CSPCa的风险增加,即使有PIRADS 1-2 mpMRI发现.
诺米图支持个性化风险评估和活检决策.

关键词:

前列腺新生体前列腺新生体多参数磁共振成像多参数磁共振成像活检是为了检查生物质.

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