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Updated: Jul 23, 2025

Large Scale Non-targeted Metabolomic Profiling of Serum by Ultra Performance Liquid Chromatography-Mass Spectrometry UPLC-MS
07:34

Large Scale Non-targeted Metabolomic Profiling of Serum by Ultra Performance Liquid Chromatography-Mass Spectrometry UPLC-MS

Published on: March 14, 2013

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方法验证和新峰值检测液态染色体质谱多属性方法的方法验证和新峰值检测

Mercy Oyugi1, Xiaoshi Wang1, Xiangkun Yang2

  • 1Office of Biotechnology Products, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD 20903, USA; Office of Testing and Research, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD 20903, USA.

Journal of pharmaceutical and biomedical analysis
|July 14, 2023
PubMed
概括

使用LC-MS映射的多属性方法 (MAM) 已被验证用于治疗性蛋白质质量控制. 该方法有效监测产品质量属性,并检测Rituximab等单克隆抗体中的杂质.

关键词:
质谱测量质量谱测量方法验证方法的验证方法.多属性方法多属性方法.新峰值检测检测的新峰值检测质量控制 质量控制 质量控制

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