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Updated: Jul 23, 2025

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暴露在 perfluoroalkyl 物质 (PFAS) 和与甲状腺激素的关系在青少年男性中

Carmen Freire¹, Fernando Vela-Soria², Francesca Castiello³

¹Department of Legal Medicine, Toxicology, and Physical Anthropology, School of Medicine, University of Granada, 18016, Granada, Spain; Instituto de Investigación Biosanitaria de Granada (ibs.GRANADA), 18012, Granada, Spain; Biomedical Research Centre, University of Granada, 18016, Granada, Spain; CIBER de Epidemiología y Salud Pública (CIBERESP), Spain.

International journal of hygiene and environmental health

|July 14, 2023

概括

青少年男性暴露于和多基物质 (PFAS) 与增加的自由甲状腺素 (T4) 水平有关,特别是在那些摄入量较低的人群中. 由于样本规模较小,需要进一步研究.

科学领域:

环境健康环境健康
内分泌学在内分泌学.
儿科健康儿科健康

背景情况:

在消费品中普遍存在和多基基物质 (PFAS).
青少年接触PFAS可能会影响对大脑发育至关重要的甲状腺激素.

研究的目的:

研究青少年男性血PFAS度与甲状腺激素水平 (T3,自由T4,TSH) 之间的关联.
检查单个PFAS及其混合物对甲状腺功能的影响,考虑到状态.

主要方法:

129名青少年男性 (15-17岁) 来自INMA-格拉纳达出生队列.
测量十个PFAS和血清甲状腺激素.
线性回归和量子g计算模型,用作为潜在的效果修饰剂.

主要成果:

PFOS和PFOA是最为丰富的PFAS.
PFOA和PFUnDA与增加的自由T4水平有关.
该PFAS混合物显示,与较低摄入量的男孩的自由T4增加有关.

结论:

PFAS暴露,单独或作为混合物,与青少年男性低摄入量的自由T4升高相关.
该研究强调了PFAS和状态在甲状腺激素水平之间潜在的相互作用,尽管由于样本大小的限制,研究结果需要确认.

关键词:

青少年青少年青少年内分泌干扰干扰内分泌系统 perfluoroalkyl 物质是一种高醇基物质.甲状腺激素甲状腺激素

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