血清IL-12水平升高与IVF不良结果有关
Li Wu1, Dongyan Liu1, Xuhui Fang1
1Reproductive and Genetic Hospital, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China.
Journal of reproductive immunology
|July 14, 2023
概括
高血清中介质素-12 (IL-12) 水平与体外受精 (IVF) 结果较差有关. 升高的IL-12可能会对胚胎发育和粒粉细胞功能产生负面影响,这表明查可能有好处.
科学领域:
- 生殖免疫学 生殖免疫学
- 在体外受精 (IVF)
- 细胞因子信号传递
背景情况:
- 介质蛋白-12 (IL-12) 在各种妊娠并发症中起作用.
- 高血清IL-12和体外受精 (IVF) 结果之间的关联需要进一步调查.
研究的目的:
- 为了确定血清中升高的介质素-12 (IL-12) 水平是否与体外受精 (IVF) 周期的不良结果相关.
- 探索血清IL-12对患者特征,免疫标记,试管婴儿实验室参数和怀孕成功的影响.
主要方法:
- 对高血清IL-12的不孕妇女与接受试管婴儿治疗的输卵管因子不孕症的对照进行比较.
- 对血清和卵泡液IL-12水平,其他与免疫相关的细胞因子和粒粉细胞亡的分析.
- 试管婴儿实验室指标和临床怀孕结果的评估.
主要成果:
- 血清IL-12高的女性表现出卵细胞和胚胎产量减少,包括更少的完美和可用的胚胎和更低的胚胎形成率.
- 在高IL-12组中观察到Th1,Th2和Th17细胞因子的血清水平升高.
- 毛囊液IL-12与血清IL-12正相关,IL-12在体外诱导了花状细胞的亡.
结论:
- 高血清中介质素-12 (IL-12) 水平与体外受精 (IVF) 成功的降低有关.
- 通过促进颗粒细胞细胞亡,IL-12可能会对试管婴儿的结果产生不利影响.
- 建议考虑早期的细胞因子查,特别是IL-12,以及为IVF-ET量身定制的患者咨询.
关键词:
细胞灭亡 (apoptosis) 是一种死亡的过程.颗粒素细胞是颗粒素的细胞.在IL-12中,IL-12是最重要的.试管婴儿的结果炎症性细胞因子是可以引起炎症的.这是一个很好的方法. Th1 Th1 Th1更多相关视频
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