相关实验视频
Updated: Jul 23, 2025
10:19
Derivation of Mouse Trophoblast Stem Cells from Blastocysts
Published on: June 8, 2010
18.3K
从多能干细胞和体细胞获得人体热囊细胞干细胞状态的获取
Moriyah Naama1, Yosef Buganim1
1Department of Developmental Biology and Cancer Research, The Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel.
Current opinion in genetics & development
|July 14, 2023
概括
最近的进展使得从各种来源,包括干细胞和重新编程的体细胞,提取人体热囊细胞干细胞 (hTSCs) 成为可能. 这项研究扩大了对人类早期发育和胎盘形成的理解.
科学领域:
- 生殖生物学 生殖生物学
- 发展生物学 发展生物学
- 干细胞科学 干细胞科学
背景情况:
- 从历史上看,道德约束和有限的体外模型阻碍了人类胚胎植入和早期胎盘的研究.
- 最近的突破已经大大提高了对人类早期热囊细胞发育的理解.
- 自行更新的人类巨细胞干细胞 (hTSCs) 的衍生和培养已经成为可行的.
研究的目的:
- 审查最近在获得人类热细胞干细胞 (hTSCs) 的进展.
- 专注于从天真和原始化的人类多能干细胞 (hPSCs) 衍生hTSC.
- 讨论将体细胞重新编程成诱导的hTSCs.
主要方法:
- 总结最近关于hTSC衍生策略的文献.
- 分析方法包括从胚芽细胞,早期热囊细胞组织,hPSC和体细胞衍生.
- 评估每个衍生方法的优缺点.
主要成果:
- 现在有多种方法可以用于hTSC衍生,包括从hPSC和重编程体细胞.
- 每种方法都有独特的好处和挑战,这些好处和挑战都会影响研究的可访问性和效率.
- 该评论强调了在生成模仿早期热囊细胞发育的干细胞方面的进展.
结论:
- 最近的进展已经克服了研究人类胚胎植入和胎盘的先前局限性.
- 来自各种来源的hTSCs,特别是hPSCs和重编程体细胞的衍生,为研究提供了强大的工具.
- 未来的研究可能会探索类似于皮的hTSCs,代表植入前质细胞.
相关概念视频
01:10Zygotic Development And Stem Cell Formation
5.3K
The development of all multicellular organisms starts with the fusion of haploid cells called sperm and egg to form a diploid zygote. A zygote is a totipotent cell that can develop into a complete organism. The zygote undergoes cell division or cleavage to form an 8-cell mass. Until this stage, the cells are spherical, loosely attached, and remain totipotent. Totipotent cells are capable of developing both the embryonic and the extraembryonic tissues. However, as they continue to divide, they...
5.3K
01:06Induced Pluripotent Stem Cells
4.2K
Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic...
Somatic...
4.2K
01:27Source And Potency Of Stem Cells
4.9K
Stem cells are undifferentiated cells with extensive self-renewal properties that help them maintain their population during the fetal and adult stages of life. They can specialize in all cell types of the human body. However, their differential potential may vary and can be classified into five types. Stem cells can be (1) Totipotent, (2) Pluripotent, (3) Multipotent, (4) Oligopotent, and (5) Unipotent. Each stem cell has a specific origin; the fertilized egg or zygote is a totipotent cell and...
4.9K
01:17Stem Cell Culture
5.2K
Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
5.2K
00:58Embryonic Stem Cells
28.8K
Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
28.8K
01:14Maintenance of the ES Cell State
2.2K
The cells of the blastocyst inner cell mass only remain pluripotent for a short time. This state of pluripotency and self-renewal can be maintained in embryonic stem (ES) cell culture by adding specific chemicals or growth factors to ensure the cells can continue dividing and later differentiate into different cell types. In some cases, the cells are grown on a feeder layer of differentiated cells, which provides the growth factors and extracellular matrix components necessary for stem cell...
2.2K