在癌症中,LncRNAs和JAK-STAT信号通路之间的交叉对话
Ahmed Hjazi1, Rasha Fadhel Obaid2, Sally Saad Ali3
1Department of Medical Laboratory Sciences, College of Applied Medical Sciences, Prince Sattam bin Abdulaziz University, Al-Kharj 11942, Saudi Arabia.
Pathology, research and practice
|July 14, 2023
概括
长非编码RNAs (lncRNAs) 通过影响Janus激酶 (JAK) -信号转换器和转录激活器 (STAT) 途径来调节基因表达并影响癌症的发展. 了解这种复杂的相互作用为癌症治疗提供了潜在的新治疗点.
科学领域:
- 分子生物学分子生物学
- 癌症研究 癌症研究
- 遗传学 遗传学 是一个
背景情况:
- 长非编码RNAs (lncRNAs) 是参与细胞活动的基因表达的关键调节者.
- 新出现的证据将lncRNA与瘤发生联系起来,特别是通过调节Janus激酶 (JAK) - 信号传感器和转录激活器 (STAT) 途径.
研究的目的:
- 审查 lncRNAs 和 JAK-STAT 信号通路在癌症中的相互调节和功能.
- 为了突出这一协会最近的研究进展.
主要方法:
- 在癌症中调查lncRNA和JAK-STAT通路相互作用的研究文献综述.
- 分析 lncRNAs 如何调节 JAK-STAT 信号组件和下游效应器.
- 检查lncRNAs在瘤发生和瘤抑制中的双重作用.
主要成果:
- lncRNAs可以直接或间接地影响JAK-STAT通路,影响细胞增殖,细胞亡,迁移,入侵和上皮-介质酶过渡.
- lncRNAs也可以作为JAK-STAT通路的下游效应体,调解瘤发生.
- 在不同的癌症类型中,lncRNAs和JAK-STAT信号传递之间的特定关系有所不同.
结论:
- 在癌症中,lncRNAs和JAK-STAT通路之间的相互作用是复杂的,并且取决于环境.
- 进一步了解这种关联可能会确定癌症治疗中临床干预的新型治疗点.
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