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Updated: Jul 23, 2025

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整个蛋白质组的结构分析确定了氨酸为重点的化学蛋白质组学中弹头和覆盖范围的特定偏差

Matthew E H White1, Jesús Gil2, Edward W Tate3

  • 1Department of Chemistry, Molecular Sciences Research Hub, Imperial College London, London W12 0BZ, UK; MRC London Institute of Medical Sciences (LMS), London W12 0NN, UK.

Cell chemical biology
|July 14, 2023
PubMed
概括

使用反应性氨酸概况的共价药物发现正在扩大,但目前的方法只探索人类蛋白质组中很少一部分潜在的标. 未来的研究应该专注于增加囊类残留物覆盖范围的深度和广度,以便更广泛地发现配体.

关键词:
化学蛋白质组学化学组学共同的药物发现.同价抑制剂是共价抑制剂.同价核弹头的核弹头赛斯泰因的分析分析碎片选 碎片选 碎片选 碎片选可以结合的氨基酸.有活性氨基酸的反应性氨基酸.

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A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
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