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肠道微生物群调节糖尿病患者的远距离对称多神经病变

Junpeng Yang¹, Xueli Yang¹, Guojun Wu²

¹Department of Endocrinology, Henan Provincial Key Medicine Laboratory of Intestinal Microecology and Diabetes, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, Henan 450003, China.

Cell metabolism

|July 14, 2023

概括

来自健康捐赠者的便微生物群移植显著改善了患者的远距离对称性多神经病变 (DSPN),独立于血糖控制. 与丁酸盐生产和内毒素合成相关的特定肠道细菌集团似乎对治疗效果至关重要.

科学领域:

微生物学微生物学
神经学神经学
胃肠病学胃肠病学

背景情况:

远距离对称性多神经病变 (DSPN) 是糖尿病 (DM) 的常见并发症,病原性机制不明.
肠道微生物群在DSPN病变发生中的作用及其作为治疗点的潜力在很大程度上仍未被探索.

研究的目的:

调查肠道微生物群在DSPN病变发生中的作用.
评估便微生物群移植 (FMT) 对缓解DSPN的疗效.
为了确定与DSPN严重程度和治疗反应相关的特定肠道细菌协会.

主要方法:

一个随机,双盲,安慰剂对照试验 (ChiCTR1800017257) 涉及DSPN患者从健康的捐赠者接受FMT.
在db/db小鼠中使用DSPN患者的肠道微生物群诱导DSPN表型.
肠道细菌基因组与临床分数 (TCSS) 和肠道屏障完整性标记物的相关性分析.

主要成果:

无论血糖控制如何,FMT在患者中显著缓解了DSPN.
来自DSPN患者的肠道微生物群在小鼠中诱导了更严重的神经病变表型.
确定了两个相互竞争的细菌协会:增加的协会1 (酸盐生产) 和减少的协会2 (内毒素合成),与改善的结果,肠道屏障完整性和减少的炎症相关.
捐赠者和接受者之间匹配的肠型增强了治疗疗效.

结论:

肠道微生物群的改变在DSPN中起着起因作用.
便微生物群移植是DSPN的一个有前途的治疗策略,可能通过调节特定的细菌协会.
准这些肠道细菌协会为糖尿病中DSPN管理提供了一条新的治疗途径.

关键词:

在糖尿病中,糖尿病是血糖类的.远距离对称性多神经病变便微生物群移植吉尔德组织的组织.我们的肠道微生物组.

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