人类NK细胞中的类似收费受体8 (TLR8):对癌症免疫疗法的含义
Irene Veneziani1, Claudia Alicata1, Lorenzo Moretta1
1Tumor Immunology Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
收费类受体 (TLRs) 激活自然杀手 (NK) 细胞,特别是CD56明亮NK细胞,增强抗瘤免疫力. 向TLR可以调节瘤微环境,以改善癌症免疫疗法.
科学领域:
- 免疫学 免疫学 免疫学
- 细胞生物学 细胞生物学
- 癌症研究 癌症研究
背景情况:
- 收费类受体 (TLR) 对免疫反应至关重要,主要研究的是像树突细胞 (DC) 这样的抗原呈现细胞 (APC).
- 最近的研究强调了自然杀手 (NK) 细胞中的TLR表达和功能,调节它们的抗病原体能力.
- 在组织和瘤微环境 (TME) 中普遍存在的CD56brightNK细胞,通过内体TLR8激动剂显著激活.
研究的目的:
- 审查最近关于人类NK细胞表达的托尔类受体 (TLR) 的文献.
- 探索TLRs作为癌症疫苗和结合瘤免疫疗法的辅助剂的潜力.
- 讨论TLRs在调节NK-DC轴和瘤微环境中的作用.
主要方法:
- 对研究人类NK细胞TLR的文献综述.
- 对NK细胞激活,细胞因子产生,增殖和细胞毒性由TLR激动剂诱导的数据的分析.
- 在TLR激活的背景下,研究DC和NK细胞之间的相互作用.
主要成果:
- 内体TLR8激动剂强烈激活CD56明亮NK细胞,增加促炎性细胞因子的产生,扩散和细胞毒性.
- 受到TLR激活的影响,DC和NK细胞之间的相互作用促进DC成熟和NK细胞激活.
- 基于TLR的免疫疗法策略可以诱导促炎性TME,增强抗瘤免疫反应.
结论:
- 人类NK细胞上的TLRs代表了癌症免疫治疗的有希望的目标.
- 通过TLRs激活NK-DC轴可以通过改善抗原呈现和NK细胞细胞毒性来增强抗瘤免疫力.
- 基于TLR的方法有可能作为癌症疫苗和联合免疫疗法的辅助剂.
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