为了在技术指南中更好地考虑内分泌干扰,以获得环境质量标准
Regulatory toxicology and pharmacology : RTP
|July 14, 2023
概括
内分泌干扰化学物质 (EDC) 对人类和野生动物健康构成重大风险. 根据水框架指令的现行环境质量标准 (EQS) 往往无法考虑EDC属性,因此需要改进评估方法.
科学领域:
- 环境化学环境化学
- 毒理学 毒理学 毒理学
- 环境政策 环境政策
背景情况:
- 内分泌干扰化学物质 (EDC) 对人类健康和野生动物构成重大和持久的风险.
- 水生生态系统和食物链特别容易受到EDC污染.
- 欧洲水框架指令 (WFD) 旨在保护水体和人类健康免受污染物的侵害.
研究的目的:
- 分析在WFD下推导环境质量标准 (EQS) 中对内分泌干扰性质的考虑.
- 发现当前EDC对水质的风险评估中的不一致性和差距.
- 提出一种方法来改进EDC评估在EQS衍生.
主要方法:
- 对已知具有内分泌干扰证据的物质的现有EQS值进行文献审查和分析.
- 与已建立的内分泌干扰标准对导出的EQS值进行比较.
- 开发一种系统方法,将内分泌干扰性质纳入环境质量标准计算中.
主要成果:
- 在不同物质如何处理EDC特性方面观察到显著的异质性.
- 环境质量标准 (EQS) 是由不考虑内分泌干扰性质的70%的评估物质获得的.
- 目前的方法表明,EDC危害在水质标准中缺乏一致的整合.
结论:
- 根据WFD现有的环境质量标准衍生过程不足以解决内分泌破坏性化学物质带来的风险.
- 提出了修订后的方法,以系统地将内分泌干扰性质和相关的不确定性纳入EQS值.
- 实施这种方法将加强对水生环境和人类健康的保护,防止EDC污染.
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