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来自Hypericum sampsonii Hance的多环多烯酸乙糖及其抗炎活性

Yanzhen Li¹, Mingqiang Wang¹, Jianhui Su¹

¹School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou 510006, China.

|July 14, 2023

概括

研究人员从Hypericum sampsonii中确定了35种化合物,其中包括6种新化合物. 一些化合物通过在细胞模型中抑制氧化产生的抗炎作用.

科学领域:

自然产品化学自然产品化学
药理学药理学是一个学科.

背景情况:

众所周知,Hypericum物种是生物活性化合物的来源.
多环多烯酸酸醇 (PPAP) 是一种具有多种生物活性的自然产品.

研究的目的:

为了对Hypericum sampsonii进行植物化学调查.
为了隔离和表征新的PPAP.
评估隔离化合物的抗炎潜力.

主要方法:

使用UV,IR,NMR和HRESIMS进行植物化学分析.
通过光谱数据和计算的ECD分析来阐明结构.
在使用LPS诱导的RAW264.7细胞进行体外抗炎试验.

主要成果:

分离了35种PPAP,其中包括6种新化合物 (1, 3, 5, 15-17).
化合物1和26显著抑制了氧化 (NO) 生产.
化合物1和26抑制了可诱导的氧化合成酶 (iNOS) 和循环氧化酶-2 (COX-2) 的蛋白质表达.

结论:

桑普森 (Hypericum sampsonii) 是各种PPAP的丰富来源.
化合物1和26具有显著的抗炎性质.
这项研究强调了H. sampsonii衍生的化合物对炎症状况的治疗潜力.

关键词:

它具有抗炎活性,具有抗炎活性.这种植物名为Hypericum sampsonii 汉斯·桑普索尼.聚环多乙烯酸化乙烯基氨基醇 (Polycyclic polyprenylated acylphloroglucinols) 是一种多环多乙烯酸的化合物.

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