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脂肪和超越:一个沉默的流行病
Nang San Hti Lar Seng1, Petras Lohana1, Shruti Chandra1
1Division of Nephrology, Department of Medicine, Jacobi Medical Center at Albert Einstein College of Medicine Bronx, NY.
The American journal of medicine
|July 14, 2023
概括
肥胖是病的主要危险因素,通过炎症和纤维化引起复杂的损伤. 与肥胖相关的脏疾病的有效治疗方法包括改变生活方式,药物和减肥手术.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 内分泌学 在内分泌学.
- 病理生理学 病理生理学
背景情况:
- 肥胖患病率的上升与肥胖相关脏疾病 (ORKD) 的发病率增加有关.
- 肥胖通过复杂的机制独立导致慢性病 (CKD).
- ORKD包括与肥胖相关的淋巴细胞病和脂肪脏疾病.
研究的目的:
- 为了阐明ORKD的病理生理学.
- 审查ORKD的临床结果和当前的治疗策略.
- 突出ORKD作为公共卫生问题日益关注的问题.
主要方法:
- 关于肥胖和脏疾病的现有文献的综述.
- 对病理生理路径的分析,包括改变的血液动力学,RAAS过度激活和阿迪波基因.
- 检查临床表现和病理发现.
- 综合现有和新兴的治疗干预措施.
主要成果:
- 与肥胖相关的淋巴结核病包括过,导致淋巴结核病和潜在的焦点淋巴结核硬化.
- 脂肪病是由于外宫脂肪的积累导致的,这有助于CKD.
- 减肥和蛋白尿管理是治疗的核心,无论特定的ORKD亚型如何.
结论:
- 由于肥胖流行病,ORKD是一个显著且日益增长的健康问题.
- 综合性治疗策略至关重要,结合生活方式修改,药物治疗和手术选择.
- 新型疗法在管理和潜在地预防ORKD的进展方面具有前景.
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