带有多个肺炎球菌血型的鼻菌殖民和秘鲁幼儿的肺炎球菌总殖民密度之间的关联
Leigh M Howard1, Xiang Huang2, Wencong Chen3
1Department of Pediatrics, Vanderbilt University Medical Center, Nashville, USA.
概括
肺炎球菌共同殖民,在鼻中存在多个Streptococcus pneumoniae血清型,在年幼的秘鲁儿童中很常见. 然而,共同殖民并没有导致更高的细菌负载,这表明不同血清型的不同殖民动态.
科学领域:
- 儿童传染病 儿童传染病
- 微生物学 微生物学
- 流行病学 流行病学
背景情况:
- 鼻 (NP) 肺炎球菌殖民是疾病传播的关键因素.
- 了解共殖民及其对细菌密度的影响,对于制定有效的预防策略至关重要.
研究的目的:
- 调查鼻肺炎球菌共同殖民与秘鲁幼儿肺炎球菌密度之间的关联.
- 确定影响肺炎球菌密度和共殖民模式的因素.
主要方法:
- 前性队列研究,涉及每月从3岁以下的儿童收集NP抽样.
- 用培养物丰富的微阵列和lytA聚合酶链反应 (PCR) 用于肺炎球菌检测,血清定型和密度评估.
- 多变量混合效应线性回归模型用于分析共同殖民和密度之间的关联,控制共变量.
主要成果:
- 在53%的样本中检测到肺炎球菌,在20%的阳性样本中观察到共殖民.
- 肺炎球菌密度在急性呼吸道疾病 (ARI) 期间更高,并且随着年龄的增长而增加.
- 肺炎球菌密度和共殖民之间没有发现显著的关联 (系数0.22,95% CI 0.11-0.55).
- 血清型23B和19F更频繁地被检测为单个分离物.
结论:
- 肺炎球菌共同殖民在幼儿中很普遍,但与肺炎球菌密度增加无关.
- 个别的肺炎球菌血清型表现出不同的共同殖民倾向.
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