用于止痛药的水凝装置,具有现场加载和聚合
Scott Grindy1, Dmitry Gil1, Jeremy Suhardi1
1Harris Orthopaedics Laboratory, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Orthopaedic Surgery, Harvard Medical School, Harvard University, Boston, MA 02115, USA.
概括
这项研究开发了一种可注射的水凝,用于局部缓解疼痛,减少对阿片类药物的依赖. 这种新系统有效地提供止痛药和NSAIDs,显示了骨科疼痛管理的前景.
科学领域:
- 生物材料科学 生物材料科学
- 药物输送系统 药物输送系统
- 整形外科手术 整形外科手术
背景情况:
- 阿片类药物成的高患病率需要替代性疼痛管理策略.
- 当地药物交付提供了一种有希望的方法来减少系统性阿片类药物使用.
- 骨科应用需要有效和安全的疼痛管理解决方案.
研究的目的:
- 探索一种现场聚合水凝,用于局部输送止痛药和NSAIDs.
- 评估这种水凝系统在骨科疼痛管理中的潜力.
- 在疼痛管理中减少对全身阿片类药物的需求.
主要方法:
- 使用微波辐射合成甲基化寡合聚乙烯甘-co-乳酸聚合物.
- 包括布皮瓦卡因化物 (止痛药) 和凯托洛拉克甲胺 (NSAID).
- 在体外评估药物化,凝降解和骨质细胞生物相容性;在体内进行组织学分析和药物动力学建模.
主要成果:
- 在体外特征化药物化和凝降解概况.
- 在体外和体内通过皮下植入证明与骨质母细胞的生物相容性.
- 估计的关节内和全身药物度和药物动力学参数.
结论:
- 在现场应用的水凝显示出延长局部止痛药疗效的潜力.
- 这种水凝系统可以显著减少对阿片类药物治疗疼痛的依赖.
- 开发的水凝是骨科应用中局部疼痛缓解的有希望的工具.
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