C21类固醇来自Marsdenia tenacissima根的植物
Jin-Ling Liu1, Hong-Tao Xu2, Dan-Dan Mu3
1The MOE Key Laboratory of Standardization of Chinese Medicines and SATCM Key Laboratory of New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica (ICMM), Shanghai University of Traditional Chinese Medicine (SHUTCM), PR China.
研究人员从Marsdenia tenacissima根中发现了16种新的孕妇类固醇. 一种化合物,marsectohexol衍生物12,对肺癌细胞表现出显著的抗癌活性.
科学领域:
- 植物化学 植物化学
- 自然产品 化学 化学
- 药用化学 医学化学
背景情况:
- 马斯迪亚坚是生物活性化合物的植物来源.
- 孕妇类固醇是一种具有多种生物活性的自然产品类.
研究的目的:
- 从Marsdenia tenacissima中分离和描述新的C21类固醇.
- 评估隔离化合物对癌症细胞系的体外抗增殖作用.
主要方法:
- 使用溶剂提取和染色学进行植物化学研究.
- 通过NMR光谱,HR-ESI-MS和X射线衍射阐明结构.
- 针对HepG2,A549和MCF-7细胞系的体外抗增殖试验.
主要成果:
- 隔离了16种新的孕妇C21类固醇 (1-16) 和11种已知的类似物 (17-27).
- 化合物12是一种马塞克托赫索尔衍生物,对A549肺癌细胞 (IC50 = 5.2μM) 显示出显著的细胞毒性.
- 其他化合物表现出中度细胞毒性活动.
结论:
- 马斯迪亚 tenacissima 是结构上多样化的孕妇类固醇的丰富来源.
- 马塞克托赫克索尔衍生物12显示出作为抗癌剂的潜力,特别是在肺癌中.
- 进一步调查这些类固醇的抗癌性质是有必要的.
更多相关视频
11:14Rapid High-throughput Species Identification of Botanical Material Using Direct Analysis in Real Time High Resolution Mass Spectrometry
Published on: October 2, 2016
07:29HPLC Coupled with Chemical Fingerprinting for Multi-Pattern Recognition for Identifying the Authenticity of Clematidis Armandii Caulis
Published on: November 11, 2022
相关概念视频
Plant Hormones
Hormones of the Adrenal Glands
The adrenal cortex, a powerhouse of hormone synthesis, generates over two dozen corticosteroid hormones. The zona glomerulosa produces mineralocorticoids, exemplified by aldosterone, influencing the electrolyte composition of body fluids. The synthesis of glucocorticoids such as cortisol and...
Meristems and Plant Growth
Basic Plant Anatomy: Roots, Stems, and Leaves
Drugs Acting on Autonomic Ganglia: Stimulants
Ganglionic stimulants activate NM nicotinic receptors in autonomic ganglia, falling into two categories: nicotine mimetics [e.g., lobeline, dimethylpiperazine, tetramethylammonium] and muscarinic receptor agonists [e.g., muscarine, methacholine]. The first category's action is rapid and blocked by nicotinic receptor antagonists, while the second category's action is delayed and blocked by atropine-like agents. Nicotine, an alkaloid, affects the heart rate by stimulating...
Hormones of the Pituitary Gland
The most abundantly secreted hormone from the anterior lobe is the growth hormone, which controls overall growth by...
