环境细颗粒物和怀孕结果:一个总体审查
Shuaixing Song1, Zhan Gao2, Xiaoan Zhang3
1The Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou, China; College of Public Health, Zhengzhou University, Zhengzhou, China.
Environmental research
|July 14, 2023
概括
怀孕期间接触细颗粒物 (PM2.5) 与低出生体重和出生缺陷等不良出生结果有关. 它还增加了妊娠并发症的风险,如孕前.
科学领域:
- 环境健康 环境健康
- 生殖健康 生殖健康
- 流行病学 流行病学
背景情况:
- 越来越多的证据将环境细颗粒物 (PM2.5) 暴露与不良妊娠结果联系起来.
- 现有的研究需要对特定的出生缺陷和妊娠并发症进行细化.
研究的目的:
- 改进关于PM2.5与出生缺陷之间的联系的证据.
- 总结关于PM2.5和怀孕并发症的研究可信度.
- 根据怀孕三个月进行子组分析.
主要方法:
- 系统性审查和元分析的综合性审查 (PubMed,科学网络,Embase,Cochrane).
- 在2022年3月16日之前搜索文献,遵守PRISMA指南.
- 使用AMSTAR 2和GRADE标准评估方法和证据质量.
主要成果:
- 确定了41个系统性审查 (28个关于出生结果,13个关于妊娠并发症).
- 暴露于PM2.5与低出生体重,早产,死产,对于妊娠年龄来说小,和出生缺陷有关.
- 观察到高血压疾病,妊娠期糖尿病,妊娠期高血压和孕前的风险增加.
结论:
- 暴露于环境PM2.5显著增加了不良分娩结果和妊娠并发症的风险.
- 暴露于PM2.5对怀孕结果的影响在三个月内有所不同.
- 调查结果强调需要加强围产期医疗保健,解决空气污染问题,促进代际公平.
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