在过度饮食发作的人中,奖励和抑制控制网络之间的有效连接性发生变化:光谱动态因果建模研究
Ximei Chen1, Wei Li1, Yong Liu1
1Key Laboratory of Cognition and Personality, Ministry of Education, Southwest University, Chongqing, China.
Appetite
|July 14, 2023
概括
暴饮暴食的个体表现出大脑连接的改变. 奖励网络是一个奖励网络.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 行为科学 行为科学
背景情况:
- 过度饮食与改变大脑连接有关,影响行为控制和奖励处理.
- 在暴饮暴食中,奖励和抑制控制系统之间的精确的方向相互作用仍然不清楚.
研究的目的:
- 在成年人中调查执行控制网络 (ECN) 和奖励网络 (RN) 之间的定向连接模式.
- 探索这些连接差异如何与暴饮暴食频率有关.
主要方法:
- 休息状态功能性磁共振成像 (fMRI) 数据来自36名成年人与暴饮暴食事件和36名对照.
- 频谱动态因果建模 (DCM) 用于估计ECN和RN内的有效连接性.
- 分析集中在15个预定义的感兴趣地区,以比较群体之间的定向连接.
主要成果:
- 暴饮暴食的个体在ECN中表现出强化的积极联系.
- 在暴饮暴食组中,ECN和RN (双向) 之间的负面联系显著减弱.
- 增加的RN→ECN连接与饮食过度的频率呈正相关性,独立于年龄,性别和BMI.
结论:
- 这项研究揭示了暴饮暴食中方向性大脑网络集成的改变.
- 前额前皮下回路之间的双向抑制效应减少表明平衡抑制控制和奖励反应能力的能力降低.
- 研究结果强调了网络动态中断在暴饮暴食病理生理学中的作用.
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