环境对儿童多发性硬化症风险和病程的影响
Darina Dinov1, James Nicholas Brenton2
1Department of Neurology, Virginia Commonwealth University, Richmond, VA.
Seminars in pediatric neurology
|July 14, 2023
概括
肥胖和维生素缺乏等环境因素影响儿科多发性硬化症 (MS) 风险和进展. 了解这些因素是有效管理儿童多发性硬化症的关键.
科学领域:
- 神经学 神经学
- 环境健康 环境健康
- 儿科 儿科 儿科
背景情况:
- 儿童多发性硬化症 (MS) 占所有MS诊断的3%-10%.
- 环境因素显著影响MS风险和疾病的发展过程,儿童和成人发病的MS之间有共同的因素.
- 患有多发性硬化症的儿童提供了一个独特的环境暴露窗口,因为他们接近疾病发病和较少的混因素.
研究的目的:
- 检查特定于儿科MS的环境风险决定因素.
- 审查当前关于这些因素如何影响儿童多发性硬化症的临床演变的知识.
主要方法:
- 对MS的环境风险因素的文献综述.
- 对专注于儿童多发性硬化症病程的研究进行分析.
- 综合关于环境影响对儿科多发性硬化症演变的研究.
主要成果:
- 确定了导致儿童多发性硬化风险的关键环境因素,包括地理度,病毒暴露,肥胖,维生素缺乏,吸烟,空气污染,围产因素,肠道微生物群和饮食.
- 强调了越来越多的研究重点是这些决定因素如何影响儿童多发性硬化症的临床进展.
- 强调了研究儿科多发性硬化症的明显优势,以了解早期环境影响.
结论:
- 环境因素在儿童多发性硬化症的发病和进展中起着关键作用.
- 对这些决定因素的进一步研究对于开发有针对性的干预措施和改善MS儿童的治疗结果至关重要.
- 儿童多发性硬化症的研究为多发性硬化症的早期环境病原体提供了宝贵的见解.
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