细颗粒物成分对心肌梗塞死亡的短期影响
Shaocai Mo1, Jianlin Hu2, Chuanhua Yu3
1Department of Epidemiology and Biostatistics, School of Public Health, Wuhan University of Science and Technology, Wuhan 430065, China.
Journal of environmental sciences (China)
|July 14, 2023
概括
短期暴露于细颗粒物 (PM2.5) 和其碳状成分,元素碳 (EC) 和有机碳 (OC),显著增加了死于心肌梗塞 (MI) 的风险. 水溶性离子与心脏病发作死亡率没有显著关联.
科学领域:
- 环境健康科学 环境健康科学
- 心血管流行病学心血管流行病学
- 空气污染的毒理学
背景情况:
- 现有证据表明,短期接触细颗粒物 (PM2.5) 与心肌梗塞 (MI) 死亡风险增加有关.
- 负责这种关联的特定PM2.5成分在很大程度上仍未确定.
研究的目的:
- 确定PM2.5与心脏病发作死亡率增加风险相关的特定成分.
- 量化了短时间暴露于PM2.5及其组分与中国南部MI死亡率之间的关联.
主要方法:
- 使用一个时空分层的病例交叉设计,分析了来自中国南部32个县的12,927例MI死亡 (2011-2013).
- 使用社区多级空气质量建模系统估计了县级对PM2.5及其成分 (元素碳 (EC),有机碳 (OC),硫酸盐,,) 的暴露.
- 条件后勤回归模型量化了肌痛性心脏病死亡率和对PM2.5及其成分的3天移动平均暴露之间的关联.
主要成果:
- 在PM2.5的1-μg/m3增加与3.8%增加的MI死亡风险相关 (OR=1.038,95%CI:1.003-1.074).
- 元素碳 (EC) 和有机碳 (OC) 显示出与MI死亡率 (OR=1.038和1.057分别) 的显著关联.
- 在MI死亡率和暴露于硫酸盐,或酸盐之间没有发现显著的关联. 对于EC/OC,在老年人,男性和寒冷的月份中观察到更强烈的关联.
结论:
- 短期暴露于PM2.5,特别是其碳化合物成分 (EC和OC),与心脏病发作死亡率的风险增加有关.
- 这些发现强调了在空气污染控制战略中针对碳酸性气溶以减轻心血管风险的重要性.
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