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Updated: Jul 23, 2025

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Published on: October 23, 2018

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lysosomal cystine出口调节mTORC1信号,以指导脏上皮细胞命运专业化

Marine Berquez1, Zhiyong Chen1, Beatrice Paola Festa1

  • 1Institute of Physiology, University of Zurich, 8057, Zurich, Switzerland.

Nature communications
|July 14, 2023
PubMed
概括

从溶酶体中缺陷的囊动员会通过激活mTORC1.1,破坏细胞分化. 在囊病模型中,mTORC1的治疗抑制会纠正这些细胞命运缺陷.

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