相关实验视频
Updated: Jul 23, 2025

07:50
Chromatin Immunoprecipitation of Murine Brown Adipose Tissue
Published on: November 21, 2018
8.2K
增加的体重指数与全身炎症有关,通过人类前脂质细胞中改变的染色质共同可访问性
Kristina M Garske1, Asha Kar1, Caroline Comenho1
1Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA, 90095, USA.
Nature communications
|July 14, 2023
概括
肥胖会破坏前脂肪细胞中的染色质组织,导致炎症. 这项研究揭示了更高的体重指数 (BMI) 双胞胎中改变的染色质共存性如何通过基因环境相互作用促进炎症.
科学领域:
- 分子生物学分子生物学
- 遗传学 遗传学 是一个
- 免疫学 免疫学 免疫学
背景情况:
- 肥胖导致脂肪组织功能障碍,导致低度炎症和并发症.
- 前脂质细胞可能会导致与肥胖相关的炎症,但机制尚未完全理解.
研究的目的:
- 为了调查增加的体重指数 (BMI) 是否会改变人类前脂肪细胞中的亚核色素组织.
- 为了确定前脂肪细胞中染色质组织的改变是否有助于肥胖引起的炎症.
主要方法:
- 在人类初级前脂肪细胞上利用了ATAC序列和RNA序列,来自BMI异调单胞胎 (MZ) 双胞胎对.
- 在活跃的亚核区内分析了开放色素的共同可访问性.
- 在患有全身炎症的受影响地区的相关遗传变异,使用英国生物库数据.
主要成果:
- 在大约88.5 Mb的活性亚核区间中,在更高的BMI MZ兄弟姐妹中发现了开放色素的改变.
- 证明这些区域内的变异通过BMI相互作用导致系统性炎症 (C-反应性蛋白水平).
- 在较高BMI个体的前脂肪细胞中确定了受损的开放色素共同可访问性.
结论:
- 人类前脂肪细胞中受损的开放色素共存与更高的BMI有关.
- 表明一种新的机制,即肥胖引起的前脂肪细胞染色质组织变化有助于炎症.
- 强调了基因与环境相互作用在与肥胖相关的炎症过程中的作用.
相关概念视频
Obesity
542
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
542
Hypodermis
4.7K
The hypodermis (the subcutaneous layer or superficial fascia) is present directly below the dermis. It connects the skin to the underlying fascia (fibrous tissue) of the bones and muscles. It is not strictly a part of the skin, although the border between the hypodermis and dermis can be difficult to distinguish. The hypodermis consists of well-vascularized, loose, areolar connective tissue and adipose tissue, which functions as a mode of fat storage and provides insulation and cushioning for...
4.7K
Cholesterol: Significance and Regulation
592
Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
Considering cholesterol and...
592
Inflammation
53.9K
Overview
53.9K

