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Updated: Jul 23, 2025

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根据C3a/C3a受体的信号传导,SARS-CoV-2尖端蛋白诱导肺内皮细胞功能障碍和血栓炎症

Luca Perico1, Marina Morigi2, Anna Pezzotta2

  • 1Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Bergamo, Italy. luca.perico@marionegri.it.

Scientific reports
|July 14, 2023
PubMed
概括

在SARS-CoV-2尖端蛋白S1亚单元触发肺血管损伤通过激活补充系统. 通过C3aRa疗法阻断C3a受体可以防止这种S1诱导的肺损伤.

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