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在小鼠中Pparα淘汰会通过促进IKKα/RORγt和IKKα/Foxp3复合体来增加Th17的发展

Ping Wei1, Wei Kou1,2, Juan Fu3

  • 1Department of Otolaryngology, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders (Chongqing), China International Science and Technology Cooperation base of Child Development and Critical Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China.

Communications biology
|July 14, 2023
PubMed
概括

激活受体-α (Pparα) 的过氧体增殖器抑制了Th17细胞的分化. 它的缺乏会增强Th17细胞,在小鼠模型中恶化自身免疫性疾病,这表明Pparα是治疗点.

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