基于聚合物的双重药物输送系统,用于针对性治疗耐诺黄 Staphylococcus aureus介导的感染
Gopalakrishnan Thamilselvan1, Helma David1, Anusree Sajeevan1
1Quorum Sensing Laboratory, Centre for Research in Infectious Diseases (CRID), School of Chemical and Biotechnology, SASTRA Deemed to be University, Thanjavur, 613401, India.
Scientific reports
|July 14, 2023
概括
这项研究开发了一种智能水凝,可提供西普罗夫洛克萨 (抗生素) 和5-Nitro-2-(3-phenylpropoxy) (排泄抑制剂),用于对抗S. aureus皮肤感染和抗菌素耐药性.
科学领域:
- 生物医学工程 生物医学工程
- 材料科学 材料科学 材料科学
- 传染性疾病 传染性疾病
背景情况:
- 抗菌素耐药性的增加需要新的治疗策略.
- 黄金葡萄球菌 (S. aureus) 感染构成了重大的公共卫生挑战.
- 排泄抑制剂可以使细菌对抗生素重新敏感.
研究的目的:
- 开发一种用于治疗S. aureus皮肤感染的组合疗法.
- 使用智能水凝系统,同时输送抗生素和排泄抑制剂.
- 通过协同药物作用克服抗菌素耐药性.
主要方法:
- 用Ciprofloxacin装载的聚乙烯醇 (PVA) 水凝的制造和优化.
- 合成和特征的5-Nitro-2-(3-phenylpropoxy) 化物 (5-NPPP) 装载的Eudragit RSPO纳米粒子.
- 开发用于持续释放的双药加载PVA水凝.
- 使用Balb/c小鼠模型进行体内评估,这些小鼠患有S. aureus诱导的皮肤感染.
主要成果:
- 在5天的时间里,PVA水凝显示出持续释放的西普罗夫洛克萨.
- 装有5-NPPP的纳米粒子表现出高捕获效率 (>90%) 和最佳粒子大小 (230-280 nm).
- 在体内研究表明,双药水凝是无毒的,减少了细菌负载,并促进了重新表皮化.
结论:
- 与Ciprofloxacin和5-NPPP纳米颗粒共同装载的聚乙醇 (PVA) 水凝是一种有前途的药物输送系统.
- 这种组合方法通过使细菌对抗生素重新敏感,有效地治疗金黄色细菌的皮肤感染.
- 开发的水凝系统提供了一种潜在的解决方案,用于对抗皮肤感染中的抗菌素耐药性.
相关概念视频
01:27Combined Effects of Drugs: Synergism
4.1K
Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
Such synergistic combinations...
Such synergistic combinations...
4.1K
01:28Gene Regulation in Microbial Communities: Quorum Sensing
41
Quorum sensing is a mechanism of bacterial communication that enables coordinated gene expression in response to changes in population density. This facilitates collective behaviors that enhance survival, resource acquisition, and ecological adaptation. This process relies on small signaling molecules called autoinducers that accumulate as bacterial populations grow. When a critical threshold concentration of autoinducers is reached, bacterial cells collectively modify gene expression,...
41