绘制白质和灰质对人类大脑中静止状态网络的共同贡献的图谱
Victor Nozais1,2, Stephanie J Forkel3,4,5,6, Laurent Petit7
1Univ. Bordeaux, CNRS, CEA, IMN, UMR 5293, GIN, F-33000, Bordeaux, France. victor.nozais@gmail.com.
Communications biology
|July 14, 2023
概括
研究人员绘制了白质和灰质对静态网络 (RSN) 的贡献. 大多数白质在RSN中共享,这表明这些区域的病变可能会显著影响大脑的通信和功能.
科学领域:
- 神经成像是一种神经成像.
- 系统神经科学 系统神经科学
- 在Connectomics上,我们提供了连接.
背景情况:
- 休息状态功能磁共振成像 (fMRI) 研究已经将功能连接与认知和疾病联系起来.
- 然而,支持这些网络的底层白质结构连接尚未完全理解.
研究的目的:
- 开发一种方法,共同绘制白色和灰色物质对静态网络 (RSN) 的贡献.
- 创建一个RSN的地图,并调查它们之间的白质重叠.
- 为探索这些关系及其临床影响提供开源软件.
主要方法:
- 开发了一种新的方法,可以同时绘制白色和灰色物质的地图,这些物质对每个RSN都有贡献.
- 利用人类结合体项目的数据集生成了30个RSN的地图.
- 量化了跨多个RSN共享的白质区域的重叠.
主要成果:
- 创建了30个RSN的全面地图,详细介绍了灰质和白质的贡献.
- 发现了广泛的白质重叠,其中89%由多个RSN共享,16%由至少7个RSN共享.
- 通过将中风患者的症状与受影响的RSN及其估计功能的联系,证明了开发的软件的实用性.
结论:
- 白质的广泛重叠表明,共享区域的病变可能会深刻影响网络通信.
- 提供的地图集和开源软件有助于研究白质损伤对RSN的影响.
- 这种方法为了解神经疾病的神经支柱提供了有价值的工具.
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