心力衰竭和表观遗传年龄之间的因果关系:双向的门德尔随机化研究.
Fengjun Zhang1, Shanshan Deng2,3, Jing Zhang4
1College of Acupuncture and Massage, Shandong University of Traditional Chinese Medicine, Jinan, China.
ESC heart failure
|July 15, 2023
概括
表观遗传年龄是生物衰老的标志物,因果上增加了心力衰竭 (HF) 的风险. 这项在欧洲人口中进行的门德尔随机化研究表明,先进的表观遗传年龄预测了更高的HF发病率,突出了衰老是心脏病的关键因素.
科学领域:
- 心血管疾病流行病学
- 遗传学和衰老研究研究
- 衰老的生物标志物
背景情况:
- 心力衰竭 (HF) 是老年人常见的一种心血管疾病,预后不佳.
- 了解衰老和HF之间的因果关系对于开发有效的干预措施至关重要.
- 表观遗传年龄作为衰老的生物学标志物,与时间学年龄不同.
研究的目的:
- 使用双向门德尔随机化 (MR) 方法调查表观遗传年龄和心力衰竭 (HF) 之间的因果关系.
- 评估基因预测的表观遗传年龄是否影响患高血压风险.
- 为了确定HF是否在遗传上影响表观遗传年龄.
主要方法:
- 进行了双向门德尔随机化 (MR) 分析,使用全基因组关联研究数据对表观遗传年龄钟 (GrimAge,HorvathAge,HannumAge,PhenoAge) 和HF进行了分析.
- 反变量加权 (IVW) 方法是主要的分析方法.
- 为了确保稳定性,进行了敏感性分析,包括MR-Egger,加权中位数,异质性,留出一个和性分析.
主要成果:
- 表观基因的PhenoAge时钟显示了统计学上显著的因果关系,增加了心力衰竭 (HF) 的风险.
- 在IVW分析表明,对于预测HF的PhenoAge,赔率比 (OR) 为1.015 (95%CI为1.002-1.028,P=0.028).
- 其他表观遗传年龄测量和反向因果分析 (表观遗传年龄的HF) 没有产生统计学上显著的结果.
结论:
- 这项双向MR研究提供了证据,证明了欧洲血统个体的遗传预测表观遗传年龄和心力衰竭 (HF) 之间的因果关系.
- 这些发现表明,表观遗传年龄反映的生物衰老是导致HF发展的因素.
- 建议对多种不同人群的表观遗传年龄进行进一步的研究,并使用额外的HF遗传数据.
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