一般人口中NAFLD对死亡率和发病率的负担:基于社区的纵向研究 (NASH-CO研究)
Oumarou Nabi1,2, Nathanaël Lapidus1, Jerome Boursier3,4
1Sorbonne University, Inserm, Pierre Louis Institute of Epidemiology and Public Health (IPLESP), AP-HP, Saint-Antoine Hospital, Paris, France.
概括
非酒精性脂肪性肝病 (NAFLD) 显著增加死亡风险和严重的健康问题,如心血管疾病和慢性病. 这项研究突出显示,NAFLD是一般人群中快速增长的发病率和死亡率的原因.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 非酒精性脂肪肝 (NAFLD) 对一般人口发病率和死亡率的影响未得到充分记录.
- 这项研究调查了NAFLD与健康结果之间的关联.
研究的目的:
- 评估NAFLD和发病率之间的关联.
- 估计NAFLD对健康状况和死亡率的影响.
- 为了记录NAFLD在一般人口层面的影响.
主要方法:
- 使用了情况队列 (137,206名参与者).
- 用于NAFLD和纤维化诊断的非侵入性指数 (脂肪肝指数,福恩斯指数).
- 将队列数据与医疗保健和住院记录联系起来,以评估结果.
主要成果:
- NAFLD的患病率为18.3%;2.7%的人患有纤维化.
- 与增加的死亡率相关的NAFLD (HR 1.26),肝脏事件 (HR 2.48),心血管疾病 (HR 1.42),EHC (HR 1.11) 和CKD (HR 1.81).
- 每年NAFLD显示肝病,心血管疾病,慢性瘤和死亡率的增长趋势最快.
结论:
- 在一般人群中,NAFLD与增加的发病率和死亡率有关.
- 这项研究证实了NAFLD对整体健康状况的重大影响.
- 随着趋势的升级,NAFLD代表着日益严重的公共卫生问题.
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