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Updated: Jul 23, 2025

Modeling Myotonic Dystrophy 1 in C2C12 Myoblast Cells
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一个功能失调的miR-1-TRPS1-MYOG轴通过抑制终端肌原分化来驱动ERMS

Sören S Hüttner1, Henriette Henze1, Dana Elster1

  • 1Leibniz Institute on Aging - Fritz Lipmann Institute, Beutenbergstrasse 11, 07745 Jena, Germany.

Molecular therapy : the journal of the American Society of Gene Therapy
|July 15, 2023
PubMed
概括

转录抑制剂TRPS1在胚胎狂宫肌肉瘤中高度表达,阻碍肌肉细胞的分化. 降低TRPS1水平可以促进肌原分化,并作为这种儿科癌症的潜在治疗策略.

关键词:
在ERMS中使用ERMS.研发与开发细胞 RD细胞在 TRPS1 中.这是一个小RNARNA.肌肉干细胞是肌肉的干细胞.肌源性差异化的分化复兴再生是一种再生方式.拉布多米索科马 (rhabdomyosarcoma) 是一种肌肉癌.这是骨肌肉的骨架肌肉.

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