脂蛋白 (Lipoprotein) 是一种对心血管疾病的基因决定风险因素
1Medpace Reference Laboratories, Cincinnati, OH, USA.
Critical reviews in clinical laboratory sciences
|July 15, 2023
概括
升高的脂蛋白 (a) 是心血管疾病的遗传决定性风险因素,从童年就存在. 测量脂蛋白 (a) 对于识别有风险的个体至关重要,尽管在临床实践中使用率不足.
科学领域:
- 生物化学 生物化学
- 遗传学 遗传学 是一个
- 心脏病学 心脏病学
背景情况:
- 脂蛋白 (Lp) 是一种独特的脂蛋白粒子.
- 它与低密度脂蛋白 (LDL) 有相似之处,但由于非脂蛋白 (apolipoprotein) 的存在,它具有不同的特征.
- Lp (a) 尺寸和血度是由基因决定的,并且在很大程度上不受生活方式或药物的影响.
研究的目的:
- 为了回顾Lp的关键特征.
- 讨论其作为动脉样硬化心血管疾病 (ASCVD) 的因果风险因素的既定作用.
- 强调测量Lp (a) 对于成人和儿童风险分层的重要性.
主要方法:
- 关于Lp (a) 特性,遗传学和临床意义的研究的文献综述.
- 分析证据,将升高的Lp (a) 与ASCVD风险联系起来.
- 讨论当前的指导方针和临床实践,关于Lp.
主要成果:
- 升高的Lp (a) 是ASCVD的强烈,基因决定的风险因素.
- 高Lp(a) 水平从幼儿时期就存在,导致心血管风险过早.
- 尽管有证据和指导方针,但在临床环境中Lp (a) 测试仍然不常见.
结论:
- Lp (a) 是ASCVD的一个关键的,基因决定的风险因素.
- 在成人和青少年中查升高的Lp (a) 值对于早期识别心血管风险至关重要.
- 建议增加临床测量Lp(a) 进行全面的心血管风险评估.
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