生物降解植入物的铁金复合材料:在玻璃中研究生物降解和生物矿化
V P Muhammad Rabeeh1, Shebeer A Rahim2, Sijina Kinattingara Parambath3
1Nanomaterials Research Laboratory, School of Materials Science and Engineering, National Institute of Technology Calicut, Kozhikode 673601, India.
ACS biomaterials science & engineering
|July 15, 2023
概括
将少量黄金 (Au) 添加到铁 (Fe) 中可以显著加快基于Fe的材料的降解. 这种金色增强的铁显示了改善的生物相容性和更快的组织集成,用于可生物降解的植入物.
科学领域:
- 生物材料科学 生物材料科学
- 材料工程 材料工程 材料工程
- 生物医学工程 生物医学工程
背景情况:
- 由于其生物相容性,铁 (Fe) 是可生物降解金属植入物的有前途材料.
- 纯铁的缓慢降解率限制了其在组织再生中的应用.
- 贵金属可以通过电合提高铁的降解率.
研究的目的:
- 研究低度黄金 (Au) 对铁的降解速度和生物活性的影响.
- 评估铁金 (Fe-Au) 复合材料作为改进的可生物降解金属植入物的潜力.
主要方法:
- 在纯铁和铁样本上进行了电化学腐蚀测试,其AU值为1.25和2.37μg/g.
- 沉浸试验和电化学阻抗光谱在模拟体液 (SBF) 中进行.
- 使用L929-murine纤维细胞评估了细胞毒性.
主要成果:
- 与纯铁相比,含有Au的铁样本的降解速度是4倍和9倍的快.
- Fe-Au复合物显示出增强的生物活性,并增加了 in situ 酸酸盐的形成.
- 在暴露于Fe-Au复合物的L929-murine纤维细胞中没有观察到毒性.
结论:
- 低度的黄金有效地提高了铁的生物降解率.
- Fe-Au复合材料促进生物矿物化,并且具有良好的生物相容性.
- Fe-Au复合材料适用于定制生物降解和改进基于Fe的植入物.
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