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血小板输血和出血的预测因素在患有骨髓质疏松症候群的患者
Allison Mo1,2,3, Erica Wood1,2, Jake Shortt2,4
1Transfusion Research Unit, School of Public Health & Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
European journal of haematology
|July 15, 2023
概括
血小板缺血常见于骨髓质疏松症候群 (MDS) 中. 尽管有指导方针,但经常使用预防性血小板输血,但仍有11%的患者出现显著出血.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 内部医学 内部医学
背景情况:
- 骨髓发育综合征 (MDS) 是一组克隆性造血干细胞疾病.
- 血栓缩是MDS的常见并发症,增加出血风险.
- 血小板输血和tranexamic acid (TXA) 被用于管理,但它们在MDS中的有效性需要进一步研究.
研究的目的:
- 描述MDS患者中血小板缺血的负担.
- 评估支持性护理实践,包括血小板输血使用.
- 为了识别出血并发症和预测出血在MDS.
主要方法:
- 对179名患有MDS或相关瘤的成年患者进行了回顾性队列研究.
- 从2016年至2018年期间从医院医疗记录中收集的数据.
- 对血小板计数,输血实践,TXA使用和出血事件的分析.
主要成果:
- 15.6%的患者患有严重的血小板缺血 (<20 × 109/L).
- 预防性血小板输血对于严重的血小板缺血是常见的,这与指导方针相反.
- 11.2%的患者经历了需要住院治疗的出血事件; 血小板计数或干预措施无法预测出血.
结论:
- 血小板缺血是MDS患者的一个重要问题.
- 目前在MDS中管理血小板缺血的做法可能与指南不一致.
- 需要进一步的研究,以优化MDS的出血预防策略.
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