通过协同机制触发铁灭菌
Xin-Xin Peng1, Hang Zhang1, Ruijing Zhang2
1Beijing National Laboratory for Molecular Sciences, College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871, P. R. China.
Angewandte Chemie (International ed. in English)
|July 15, 2023
概括
(Ga-1) 通过破坏细胞膜和抑制抗氧化剂系统,触发一种细胞死亡形式的铁亡. 将Ga-1与多不和脂肪酸相结合,可以增强抗癌效果.
科学领域:
- 生物化学 生化学
- 细胞生物学 细胞生物学
- 在瘤学瘤学.
背景情况:
- 离子 (Ga3+) 传统上被认为通过干扰铁代谢来诱导细胞死亡.
- 铁亡是一种受铁含量影响的受调节细胞死亡的独特形式.
研究的目的:
- 为了研究能诱导铁亡的机制.
- 评估复合体 (Ga-1) 在癌症治疗中的治疗潜力.
主要方法:
- 研究了Ga-1作为影响细胞pH值和膜透性的离子载体的作用.
- 评估了Ga-1对线粒体功能和从电子转移链 (ETC) 释放铁的影响.
- 研究了Ga-1与内质网膜 (ER) 中的蛋白质二硫化异构酶 (PDI) 的相互作用及其对谷氨 (GSH) 系统的影响.
主要成果:
- Ga-1 充当阴离子载体,诱导线粒体功能障碍和铁素释放.
- Ga-1 抑制了PDI,损害了GSH抗氧化剂的修复,并促进了铁亡.
- 与Ga-1和多不和脂肪酸 (PUFA) 的联合治疗在体外和体内都显示出协同作用的抗癌作用.
结论:
- 可以通过涉及膜运输和ER应激的间接机制诱导铁.
- Ga-1代表了一种用于诱导瘤细胞中铁亡的新策略.
- 联合Ga-1和PUFA治疗提供了一种协同方法来增强抗瘤效应.
相关概念视频
Necrosis
4.6K
Necrosis is considered as an “accidental” or unexpected form of cell death that ends in cell lysis. The first noticeable mention of “necrosis” was in 1859 when Rudolf Virchow used this term to describe advanced tissue breakdown in his compilation titled “Cell Pathology”.
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become...
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become...
4.6K
Ligand-Gated Ion Channel Receptor: Gating Mechanism
2.3K
Ligand-gated ion channels are transmembrane proteins that play a vital role in intercellular communication and functions of the nervous system. They allow the influx of ions across the membrane once the neurotransmitter binds, allowing the subsequent transmission of electrical excitation across the neurons. Other ligand-gated ion channels, like the γ-aminobutyric acid (GABA) receptor, permit anions like chloride into the cells on the binding of the GABA molecule. Their entry into the cell...
2.3K
Ferromagnetism
2.4K
Materials like iron, nickel, and cobalt consist of magnetic domains, within which the magnetic dipoles are arranged parallel to each other. The magnetic dipoles are rigidly aligned in the same direction within a domain by quantum mechanical coupling among the atoms. This coupling is so strong that even thermal agitation at room temperature cannot break it. The result is that each domain has a net dipole moment. However, some materials have weaker coupling, and are ferromagnetic at lower...
2.4K


