迷走神经炎症有助于COVID-19中的dysautonomia
Marcel S Woo1, Mohsin Shafiq2, Antonia Fitzek3
1Institute of Neuroimmunology and Multiple Sclerosis, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Acta neuropathologica
|July 15, 2023
概括
COVID-19 感染导致迷走神经炎症,导致自主功能障碍. 这种炎症可能解释了严重疾病的严重程度和长期的COVID症状.
科学领域:
- 神经学 神经学
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
背景情况:
- 在急性COVID-19和长期COVID中,失自性是一个重要的问题.
- 与COVID-19相关的自主功能障碍的具体原因尚不清楚.
研究的目的:
- 为了调查假设,迷走神经受到COVID-19的影响,导致自主功能障碍.
- 描述COVID-19患者迷走神经的病理变化.
主要方法:
- 从COVID-19患者和对照对死后迷走神经的组织病理学分析.
- 在迷走神经中检测SARS-CoV-2RNA和炎症细胞 (单细胞).
- 用RNA测序来分析细胞反应 (神经元,内皮细胞,施万细胞).
- 对323名患者进行临床查,以确定迷走神经参与的表型.
主要成果:
- 在COVID-19患者的迷走神经中发现了SARS-CoV-2RNA和炎症单细胞.
- RNA测序揭示了神经细胞,内皮细胞和施万细胞的显著炎症反应,与病毒载荷相关.
- 在危急COVID-19的非幸存者中观察到呼吸速率下降,这表明有临床联系.
结论:
- 感染SARS-CoV-2引发了迷走神经的炎症.
- 这种迷走神经炎症有助于自主功能障碍,关键的COVID-19严重程度,以及潜在的长期COVID dysautonomia.
更多相关视频
06:43Increased Recovery Time and Decreased LPS Administration to Study the Vagus Nerve Stimulation Mechanisms in Limited Inflammatory Responses
Published on: March 29, 2017
9.9K
04:29Vagus Nerve Stimulation As an Adjunctive Neurostimulation Tool in Treatment-resistant Depression
Published on: January 7, 2019
28.7K
相关概念视频
Disorders of the Autonomic Nervous System
711
The autonomic nervous system (ANS) is an intricate network of nerves that controls functions such as the regulation of heart rate, digestion, and blood pressure regulation. When this system malfunctions, it can lead to various disorders that affect multiple bodily functions. One common feature of many autonomic disorders is the involvement of smooth blood vessels, which play a crucial role in regulating blood flow throughout the body.
Raynaud's disease, also known as Raynaud's...
Raynaud's disease, also known as Raynaud's...
711
Myocarditis I: Introduction
10
Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
10
Psychoneuroimmunology: Cardiovascular Disease
54
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
A key area of focus in PNI is the relationship between stress and coronary...
54
Autonomic Nervous System
9.0K
The autonomic nervous system (ANS) is a critical component of the peripheral nervous system, primarily responsible for regulating involuntary bodily functions and maintaining homeostasis. It functions in tandem with the central nervous system (CNS) to seamlessly coordinate various physiological processes without the need for conscious control.
The ANS comprises two main divisions: the sympathetic and parasympathetic divisions. These divisions function antagonistically to maintain a dynamic...
The ANS comprises two main divisions: the sympathetic and parasympathetic divisions. These divisions function antagonistically to maintain a dynamic...
9.0K
Myasthenia Gravis: Overview and Treatment
1.6K
Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
1.6K
Autoimmune Disorders
511
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
Concept and Mechanism of Autoimmune Diseases
The immune...
511
