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在PET/CT成像中,生理性结肠FDG吸收可以预测转移性黑色素瘤免疫治疗的反应吗?

Christos Sachpekidis¹, Christoph K Stein-Thoeringer², Annette Kopp-Schneider³

¹Clinical Cooperation Unit Nuclear Medicine, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69210, Heidelberg, Germany. christos_saxpe@yahoo.gr.

European journal of nuclear medicine and molecular imaging

|July 15, 2023

概括

来自肠道的MTV和TLG等体积PET参数可以预测黑色素瘤患者的免疫治疗反应. 脏和骨髓代谢也为整体生存提供了预后见解.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
放射学放射学是一门学科.

背景情况:

预测黑色素瘤中对免疫检查点抑制剂 (ICI) 的反应至关重要.
肠道微生物群影响免疫治疗结果,可以作为预后标志物.
评估基线[18F]FDG PET/CT在结肠和淋巴细胞器官中的吸收可能会揭示预测生物标志物.

研究的目的:

调查PET/CT基线结肠[18F]FDG吸收是否预测接受免疫治疗的转移性黑色素瘤患者的临床结果.
评估[18F]FDG在淋巴细胞器官中的吸收与患者长期存活率之间的相关性.
探索肠道微生物群标记物 (LPS) 与免疫治疗反应之间的关系.

主要方法:

119名IV期黑色素瘤患者接受基于ipilimumab的免疫疗法进行了基线[18F]FDG PET/CT.
分析包括标准化吸收值 (SUV),代谢瘤体积 (MTV) 和结肠的总损伤糖解 (TLG),以及结肠与肝脏的SUV比率 (CLR).
计算了与肝 (SLR) 和骨髓与肝 (BLR) 的SUV比率;测量了血清LPS水平.

主要成果:

低结肠SUV和CLR显示出更长的无进展生存期 (PFS) 和总生存期 (OS) 的趋势,但缺乏统计学意义.
实现疾病控制的患者与进展性疾病患者相比,结肠MTV和TLG显著降低.
较低的基线至肝的SUVmax (SLRmax) 和骨髓至肝的SUVmax (BLRmax) 与疾病控制和更长的生存期有关.
多变量分析确定了结肠MTV,结肠TLG和BLRmax作为PFS和OS的显著预测因素.

结论:

结肠基线[18F]FDG摄入量 (SUV) 不能独立预测治疗伊皮利马布的转移性黑色素瘤患者的存活率.
来自结肠的体积PET参数 (MTV,TLG) 可以识别患者实现疾病控制并与PFS相关联.
通过SLRmax和BLRmax评估的脏和骨髓中的葡萄糖代谢提供了生存的预后信息.

关键词:

我们的肠道微生物组.免疫治疗是一种免疫疗法.脂聚糖化物 (LPS) 是一种这就是MTVMTV的MTV.发生转移的黑色素瘤.聚乙烯/聚乙烯/聚乙烯这是一辆SUV,SUVSUV.这是TLG的TLG.[18F]FDG 大肠吸收量

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