在儿童和成年人的膜瘤
Marios Lampros1, Nikolaos Vlachos1, George A Alexiou2
1Department of Neurosurgery, University of Ioannina, School of Medicine, 45500, Ioannina, Greece.
Advances in experimental medicine and biology
|July 15, 2023
概括
中枢神经系统瘤 (Ependymomas) 影响成人和儿童,可能源于放射性质细胞,而不是表皮细胞. 分子分类为这些瘤提供了比传统方法更好的预后.
科学领域:
- 神经瘤学神经瘤学
- 中枢神经系统 (CNS) 瘤 中枢神经系统 (CNS) 瘤
- 瘤的分子分类
背景情况:
- 膜瘤占成人中枢神经系统瘤的5%和儿科中枢神经系统瘤的10%.
- 最近的研究表明,放射性质细胞是起源,挑战了表皮细胞理论.
- 瘤的位置有所不同:成年人的脊髓,儿科人群的内.
研究的目的:
- 总结目前对尾瘤起源,分类和临床方面的理解.
- 突出分子分类对基因病理学对预后的重要性.
- 概述临床表现,治疗目标和预后因素.
主要方法:
- 对近期关于表瘤细胞起源研究的综述.
- 分子和本病理学分类系统的分析.
- 临床表现,治疗策略和生存数据的总结.
主要成果:
- 分分子分为九个子组的分类显示出更大的临床效用和预后价值.
- 瑞拉融合阳性尾瘤代表了一个独特的分子变异.
- 预后因素包括年龄,年级和瘤的位置;儿童的内形膜瘤的预后最差.
结论:
- 分子分类对于理解表瘤行为和患者的结果至关重要.
- 总体切除是治疗的主要目标.
- 膜瘤的整体5年生存率约为60-70%.
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