相关实验视频

Updated: Jul 23, 2025

Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors

Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors

Published on: May 17, 2024

脑和脊髓的其他神经瘤

Mihail Petrov¹, Teodora Sakelarova², Venelin Gerganov^3,4

¹University Multiprofile Hospital for Active Treatment With Emergency Medicine N. I. Pirogov, Sofia, Bulgaria. mihail5rov@gmail.com.

Advances in experimental medicine and biology

|July 15, 2023

概括

神经瘤,包括神经纤维瘤和神经瘤,是常见的脊髓瘤. 恶性退化需要迅速的多学科治疗,手术结果因瘤位置而异.

科学领域:

神经学神经学
在瘤学瘤学.
病理学病理学病理学

背景情况:

神经囊瘤,包括神经纤维瘤,神经纤维瘤和脊髓周脉瘤,是显著的脊髓瘤.
神经纤维瘤是神经纤维素瘤1型 (NF1) 的特征,而神经纤维瘤与NF1或NF2有关.
脊髓神经膜瘤是最常见的内膜外膜瘤,发病率为每百万分之3-4个.

研究的目的:

审查神经瘤的特征,诊断和管理,重点关注神经纤维瘤和恶性外围神经瘤 (MPNST).
突出识别神经纤维瘤恶性退化的迹象的重要性,特别是在NF1患者中.
讨论这些罕见瘤的手术方法和多学科管理策略.

主要方法:

对神经膜瘤的文献综述,重点关注流行病学,组织病理学,临床表现和治疗方式.
对恶性转变的诊断指标的分析.
概述手术技术和多学科团队在管理MPNST中的作用.

主要成果:

神经纤维瘤,往往无症状,可以经历恶性退化,由疼痛或快速生长表明.
恶性外围神经膜瘤 (MPNST) 是一种罕见的软组织瘤,最初的症状通常是无痛的质体.
对MPNST的外科切除率因位置而异,从近脊瘤的20%到四肢瘤的95%.

结论:

早期检测和及时的手术干预对于管理神经膜瘤和MPNST至关重要.
神经外科医生,放射科医生和瘤学家之间的多学科合作对于最佳的患者结果至关重要.
了解神经纤维瘤和MPNST的特定特征,特别是在NF1的背景下,可以指导治疗决策并改善预后.

关键词:

MPNST MPNST 的意思是神经膜瘤的神经膜瘤神经纤维瘤是一种神经纤维瘤.

更多相关视频

Surgical Transplantation of Tumor Cells into the Spinal Cord of Mice

Surgical Transplantation of Tumor Cells into the Spinal Cord of Mice

Published on: December 27, 2024

Primary Culture of Human Vestibular Schwannomas

Primary Culture of Human Vestibular Schwannomas

Published on: July 20, 2014

相关概念视频

Nervous Tissue: Myelin

Nervous Tissue: Myelin

The myelin sheath is a multilayered lipid and protein covering that insulates the axon of a neuron, enhancing the speed of nerve impulse conduction. Axons without this sheath are referred to as unmyelinated. Two types of neuroglia, Schwann cells in the peripheral nervous system (PNS) and oligodendrocytes in the central nervous system (CNS) are responsible for producing myelin sheaths.
Schwann cells begin to form myelin sheaths around axons during fetal development. They wrap around a small...

Spinal Nerves: Anatomy

Spinal Nerves: Anatomy

Spinal nerves are pivotal conduits in the nervous system, bridging the central nervous system (CNS) with the peripheral nervous system (PNS). These nerves enable a complex communication network between the brain, spinal cord, and the rest of the body, facilitating sensory input, motor output, and autonomic functions.
There are 31 bilateral pairs of spinal nerves, each emerging from the spinal cord through the intervertebral foramina—openings between adjacent vertebrae. These nerves are...

Cranial and Spinal Meninges

Cranial and Spinal Meninges

The cranial and spinal meninges are complex protective structures surrounding the central nervous system (CNS), consisting of the brain and spinal cord. These meninges consist of the dura mater, the arachnoid mater, and the pia mater. They protect the CNS, provide structural support, and aid in circulating cerebrospinal fluid (CSF).
Cranial Meninges
These meningeal layers cover the cranium. The dura mater is the outermost layer of cranial meninges. It is a thick and durable membrane of dense...

Peripheral Nervous System: Ganglia and Nerves

Peripheral Nervous System: Ganglia and Nerves

The Peripheral Nervous System (PNS) is a crucial component of the body's neural network, extending beyond the central nervous system (CNS) to bridge the gap between the CNS and the external environment. It encompasses nerves, ganglia, and sensory receptors.
Nerves
The nerve is a bundle of axons that serves as the communication highway in the PNS. Each nerve is ensheathed in a protective layer of connective tissue called the epineurium. This outermost layer safeguards the nerve and supports the...

Nervous Tissue: Glial Cells

Nervous Tissue: Glial Cells

Glia, or neuroglia, are vital support cells that assist neurons in their functions. The term "glia" originates from the Greek word for "glue," reflecting their role in holding the nervous system together. These cells can be categorized into six types: four in the central nervous system (CNS) and two in the peripheral nervous system (PNS).
The CNS glial cell includes the astrocytes, the oligodendrocytes, the microglia, and the ependymal cells.
Astrocytes are star-shaped glial...

The Spinal Cord

The Spinal Cord

The spinal cord is the body’s major nerve tract of the central nervous system, communicating afferent sensory information from the periphery to the brain and efferent motor information from the brain to the body. The human spinal cord extends from the hole at the base of the skull, or foramen magnum, to the level of the first or second lumbar vertebra.